Myeloid dendritic cells in HIV-1 infection
Myeloid dendritic cells in HIV-1 infection
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DOI：
10.1097/coh.0b013e3283499d63
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发表时间：
2011-09-01
影响因子：
4.1
通讯作者：
Robbiani, Melissa
中科院分区：
文献类型：
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作者：
Derby, Nina;Martinelli, Elena;Robbiani, Melissa
综述目的髓样树突状细胞（mDC）是HIV-1感染的关键参与者。它们促进传播和扩散，同时对于识别HIV-1和启动免疫反应以对抗感染至关重要。值得注意的是，它们的免疫刺激能力可以用来设计更好的HIV-1疫苗。本文综述了mDC与HIV-1相互作用的研究进展，并对HIV-1诱导mDC功能障碍、mDC对其他细胞类型的功能障碍、mDC对病毒的感知和HIV-1对mDC的逃避机制等方面进行了综述。这些结果强调了mDC在保护免受HIV-1感染中的重要性。靶向mDCs与疫苗和定制的佐剂可能会提高质量和解剖位置引起的免疫responses.SummaryUnderstanding的HIV-1-树突状细胞相互作用的多样性，以及在靶向治疗和疫苗接种的众多进展，将有助于合理设计的方法来治疗和阻断感染。
Purpose of reviewMyeloid dendritic cells (mDCs) are pivotal players in HIV-1 infection. They promote transmission and spread and at the same time are critical for recognizing HIV-1 and initiating immune responses to fight infection. Notably, their immunostimulatory capabilities can be harnessed to design better HIV-1 vaccines. In this review, advances in these areas of mDC-HIV-1 interactions are summarized.Recent findingsNew insights into HIV-1-induced dysfunction of mDCs and dysfunctional mDC effects on other cell types, as well as novel mechanisms of viral sensing by mDCs and their evasion by HIV-1, have been uncovered. These results emphasize the importance of mDCs in protection against HIV-1 infection. Targeting mDCs with vaccines and tailored adjuvants may improve the quality and anatomical location of elicited immune responses.SummaryUnderstanding the multiplicity of HIV-1-dendritic cell interactions together with the numerous advances in targeted therapy and vaccination will help in the rational design of approaches to treat and block infection.