Abnormalities of chromosome bands 13q12 to 13q14 in childhood acute lymphoblastic leukemia
Abnormalities of chromosome bands 13q12 to 13q14 in childhood acute lymphoblastic leukemia
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DOI：
10.1200/jco.2000.18.22.3837
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发表时间：
2000-11-15
影响因子：
45.3
通讯作者：
Uckun, FM
中科院分区：
文献类型：
--
作者：
Heerema, NA;Sather, HN;Uckun, FM
目的：关于染色体13 q12 - 13 q14带的非随机缺失知之甚少为探讨急性淋巴细胞白血病（ALL）13 q12 - 14断裂点的预后意义，我们对1988年至1995年按儿童癌症组方案治疗的初诊ALL患儿进行了13 q12 -14断裂点的细胞遗传学鉴定。13 q12 -14断裂点在1，946例接受细胞遗传学数据的病例中有36例（2%）被确定。结果分析使用标准的寿命表方法。结果：17例（47%）异常13 q12 -14被归类为，根据美国国家癌症研究所（NCI），作为低风险，和15例（42%）是标准的风险;四（11%）是婴儿不到12个月的年龄。8例13 q12 -14平衡重排，27例13 q部分缺失，1例ct部分增加和部分缺失。这些患者中最常见的其他异常是异常12 p、del（bq）、del（9 p）、14 q11断点和11 q23断点。19例患者为假二倍体，10例为超二倍体，7例为亚二倍体。13 q12 -14异常患者的无事件生存率明显低于无异常患者，6年时的估计值分别为61%（SD = 14%）和74%（SD = 1%）（P = 0.04;相对风险= 1.74），然而，两组的总生存率相似（P = 0.25）。在校正NCI风险状态和倍性的多变量分析中，13 q异常的预后影响减弱（IP =.72）。结论：13 q12 -14异常可能有助于儿童ALL的白血病发生，并增加治疗失败的风险，但与其他低风险特征相关。(C)2000年，美国临床肿瘤学会。
Purpose: Little is known about nonrandom deletions of chromosome bands 13q12 to 13q14 (13q12-14) in acute lymphoblastic leukemia (ALL), We determined the prognostic significance of cytogenetically identified breakpoints in 13q12-14 in children with newly diagnosed ALL treated on Children's Cancer Group protocols from 1988 to 1995.Patients and Methods: Breakpoint in 13q12-14 were identified in 36 (2%) of the 1,946 cases with accepted cytogenetic data. Outcome analysis used standard life-table methods.Results: Seventeen patients (47%) with an abnormal 13q12-14 were classified, according to the National Cancer Institute (NCI), as poor risk, and 15 patients (42%) were standard risk; four(11%)were infants less than 12 months of age. Eight cases had balanced rearrangements of 13q12-14, 27 patients had a partial loss of 13q, and one held both ct partial gain and a partial loss. The most frequent additional abnormalities among these patients were an abnormal 12p, a del(bq), a del(9p), a 14q11 breakpoint, and an 11q23 breakpoint. Nineteen patients were pseudodiploid, 10 were hyperdiploid, and seven were hypodiploid. Patients with an abnormal 13q12-14 had significantly worse event-free survival than patients lacking such an abnormality, with estimates at 6 years of 61% (SD = 14%) and 74% (SD = 1%), respectively (P =.04; relative risk = 1.74), Overall survival, however, was similar for the two groups (P =.25). The prognostic effect of an abnormal 13q was attenuated in a multivariate analysis adjusted for NCI risk status and ploidy IP =.72),Conclusion: Aberrations of 13q12-14 may contribute to leukemogenesis of childhood ALL and confer increased risk of treatment failure but are associated with other poor-risk features. (C) 2000 by American Society of Clinical Oncology.