Estrogen Deficiency Leads to Further Bone Loss in the Mandible of CKD Mice.
Estrogen Deficiency Leads to Further Bone Loss in the Mandible of CKD Mice.
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雌激素缺乏导致 CKD 小鼠下颌骨进一步骨质流失
DOI：
10.1371/journal.pone.0148804
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Yuan Q
中科院分区：
文献类型：
--
作者：
Guo Y;Sun N;Duan X;Xu X;Zheng L;Seriwatanachai D;Wang Y;Yuan Q
背景慢性肾脏疾病（CKD）已被视为严重的公共卫生问题。雌激素是肾脏保护和骨重塑的关键因素。我们之前的研究表明CKD会损害钛种植体的愈合。本研究旨在探讨雌激素缺乏对CKD小鼠下颌骨的影响。方法选用41只11周龄雌性C57BL小鼠。5/6肾切除术和卵巢切除术（OVX）分别引起尿毒症和雌激素缺乏。8周后处死小鼠，取下颌骨进行显微ct分析和组织学检查。结果所有小鼠均成活。血清测量证实CKD组BUN显著升高，OVX进一步升高。OVX导致CKD小鼠下颌骨BV/TV和皮质厚度显著降低。综上所述，我们的研究结果表明，雌激素缺乏会导致CKD小鼠进一步的下颌骨质流失。
Background Chronic kidney disease (CKD) has been regarded as a grave public health problem. Estrogen is a critical factor for both renal protection and bone remodeling. Our previous study demonstrated that CKD impairs the healing of titanium implants. The aim of this study was to investigate the effects of estrogen deficiency on the mandibular bone in CKD mice. Methods Forty eleven-week-old female C57BL mice were used in this study. Uremia and estrogen deficiency were induced by 5/6 nephrectomy and ovariectomy (OVX), respectively. After 8 weeks, the mice were sacrificed, and their mandibles were collected for micro-CT analysis and histological examination. Results All the mice survived the experimental period. Serum measurements confirmed a significant increase in BUN in the CKD group that was further increased by OVX. OVX led to significant decreases in both the BV/TV and cortical thickness of the mandibular bone in CKD mice. Conclusion In summary, our findings indicate that estrogen deficiency leads to further mandibular bone loss in CKD mice.