The Therapeutic Potential of Carbon Monoxide for Inflammatory Bowel Disease
The Therapeutic Potential of Carbon Monoxide for Inflammatory Bowel Disease
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DOI：
10.1159/000368765
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发表时间：
2015-01
期刊：
影响因子：
3.2
通讯作者：
T. Takagi;K. Uchiyama;Y. Naito
中科院分区：
文献类型：
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作者：
T. Takagi;K. Uchiyama;Y. Naito
炎症性肠病(IBD)，包括溃疡性结肠炎和克罗恩病，是一种慢性、复发性和缓解性肠道炎症性疾病。由于IBD的确切发病机制尚不清楚，因此研究IBD的发病机制和评估新的抗炎策略是非常重要的。最近越来越多的证据表明，在包括肠道炎症在内的各种器官损伤模型中，一氧化碳(CO)可能作为一种内源性防御性气体分子来减轻炎症和组织损伤。此外，低浓度的外源性CO对肠道炎症有保护作用。这些数据提示CO可能是IBD患者的一种新的治疗分子。在这篇综述中，我们介绍了目前已知的关于一氧化碳在肠道炎症中的治疗潜力。
Inflammatory bowel disease (IBD), encompassing ulcerative colitis and Crohn's disease, are chronic, relapsing and remitting inflammatory disorders of the intestinal tract. Because the precise pathogenesis of IBD remains unclear, it is important to investigate the pathogenesis of IBD and to evaluate new anti-inflammatory strategies. Recent accumulating evidence has suggested that carbon monoxide (CO) may act as an endogenous defensive gaseous molecule to reduce inflammation and tissue injury in various organ injury models, including intestinal inflammation. Furthermore, exogenous CO administration at low concentrations is protective against intestinal inflammation. These data suggest that CO may be a novel therapeutic molecule in patients with IBD. In this review, we present what is currently known regarding the therapeutic potential of CO in intestinal inflammation.