Evidence that intrauterine and postnatal androgens affect the development of pyloric stenosis.
Evidence that intrauterine and postnatal androgens affect the development of pyloric stenosis.
复制标题
有证据表明宫内和产后雄激素影响幽门狭窄的发展。
DOI：
10.1002/bdra.10097
复制
发表时间：
2004
期刊：
影响因子：
--
通讯作者：
W. James
中科院分区：
文献类型：
--
作者：
W. James
背景
众所周知，幽门狭窄（PS）的病因包含遗传因素和环境因素。然而，尽管有大量流行病学数据，但尚未确定广泛的环境致病因素。最近，我们对胎儿生长受限的内分泌后果和性别比的内分泌决定因素的认识有所扩展。鉴于这些新的发展，似乎值得回顾一下 PS 的流行病学数据，看看这是否能为这些可疑的 PS 环境原因提供合理的假设基础。
方法和结果
1966 年以来，Ovid Medline 数据库中的搜索词“幽门狭窄”和（“流行病学”或“危险因素”）合并在一起。过去 25 年来，英国皇家医学会图书馆（伦敦）几乎每天都会阅读笔记，从而丰富了由此产生的论文中的数据。 （电子数据检索系统不会访问偶然记录的数据，例如同胞性别比）。
结论
据推测，宫内和产后早期雄激素水平高是 PS 的环境原因。
BACKGROUND
It is rather well established that the causal antecedents of pyloric stenosis (PS) contain both genetic and environmental factors. However, in spite of substantial quantities of epidemiological data, no widespread environmental causal agent has yet been established. There have been recent extensions of our knowledge of the endocrine consequences of fetal growth restriction and of the endocrine determinants of sex ratio. It seemed worth reviewing the epidemiological data on PS in the light of these new developments to see whether this would provide a basis for a plausible hypothesis on these suspected environmental causes of PS.
METHODS AND RESULTS
The search terms "pyloric stenosis" and ("epidemiology" or "risk factors") were combined on the Ovid Medline data base for the years 1966 onwards. The data from the resulting papers were augmented by notes occasioned by almost daily reading at the Library of the Royal Society of Medicine (London) for the past 25 years. (Electronic data retrieval systems do not access incidentally recorded data such as sib sex ratios).
CONCLUSIONS
It is hypothesized that high intrauterine and early postnatal androgen levels constitute an environmental cause of PS.