Palladium responsive liposomes for triggered release of aqueous contents
Palladium responsive liposomes for triggered release of aqueous contents
复制标题
用于触发释放水性内容物的钯响应脂质体
DOI：
10.1016/j.bmcl.2023.129215
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发表时间：
2023
影响因子：
2.7
通讯作者：
Smith, Bradley D.
中科院分区：
文献类型：
--
作者：
Chasteen, Jordan L.;Padilla-Coley, Sasha;Li, Dong-Hao;Smith, Bradley D.
钯（Pd）是一种很有前途的新型生物正交化学和前药活化金属催化剂。本报告描述了钯反应性脂质体的第一个例子。关键分子是一种称为Alloc-PE的新型笼化磷脂，它形成稳定的脂质体（大的单层囊泡，直径约220纳米）。用pdcl2处理脂质体可以去除化学笼，释放破坏膜稳定的二油基磷酸乙醇胺（DOPE），并触发脂质体泄漏被封装的水内容物。结果表明了利用过渡金属触发泄漏的脂质体药物递送技术的途径。
Palladium (Pd) is a promising metal catalyst for novel bioorthogonal chemistry and prodrug activation. This report describes the first example of palladium responsive liposomes. The key molecule is a new caged phospholipid called Alloc-PE that forms stable liposomes (large unilamellar vesicles, ∼220 nm diameter). Liposome treatment with PdCl2removes the chemical cage, liberates membrane destabilizing dioleoylphosphoethanolamine (DOPE), and triggers liposome leakage of encapsulated aqueous contents. The results indicate a path towards liposomal drug delivery technologies that exploit transition metal triggered leakage.