Reversal learning after prenatal or postnatal alcohol exposure in juvenile and adult rats
Reversal learning after prenatal or postnatal alcohol exposure in juvenile and adult rats
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DOI：
10.1016/j.alcohol.2006.05.005
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发表时间：
2006-02-01
期刊：
影响因子：
2.3
通讯作者：
Hannigan, John H.
中科院分区：
文献类型：
--
作者：
O'Leary-Moore, Shonagh K.;McMechan, Andrew P.;Hannigan, John H.
Learning tasks that require the reversal of a previously learned contingency are disrupted in animals and humans exposed to alcohol during the perinatal period.目前的实验研究了不同的酒精暴露时间和受试者接受测试的年龄如何影响 T 迷宫任务中逆转缺陷的表达。各组大鼠在妊娠第 8 天至 GD20 或出生后第 4 天至 PN9 期间接触酒精，然后在 PN28 或 PN63 进行空间逆转任务测试。结果表明，在受测年龄的男性或女性中，产前接触酒精不会导致显着的剂量依赖性逆转学习缺陷。然而，在产后早期（相当于人类神经发育的妊娠晚期）接触酒精会选择性地扰乱 PN28 雄性大鼠的逆转学习表现，但不会扰乱 PN63 雄性大鼠的逆转学习表现。当受试者在 PN63 进行测试时，发现了统计学上显着的性别差异。这些结果表明，接触酒精的时间如何导致与胎儿酒精效应相关的学习缺陷的年龄依赖性表达的变化。 (c) 2006 Elsevier Inc. 保留所有权利。
Learning tasks that require the reversal of a previously learned contingency are disrupted in animals and humans exposed to alcohol during the perinatal period. The current experiments examined how varying the time of alcohol exposure and the age at which subjects were tested would affect the expression of reversal deficits in a T-maze task. Groups of rats were exposed to alcohol from gestational day (GD) 8 to GD20 or from postnatal day (PN) 4 to PN9, and then tested in a spatial reversal task at either PN28 or PN63. Results indicate that exposure to alcohol during the prenatal period did not lead to substantial dose-dependent reversal learning deficits in males or females at either age tested. However, exposure to alcohol during the early postnatal period, a period that corresponds to the third trimester in human neural development, selectively disrupted reversal learning performance in male rats at PN28 but not PN63. Statistically significant sex differences were seen when subjects were tested at PN63. These results demonstrate how the timing of alcohol exposure leads to variability in the age-dependent expression of learning deficits associated with fetal alcohol effects. (c) 2006 Elsevier Inc. All rights reserved.