Patterns of innervation of neurones in the inferior mesenteric ganglion of the cat.
Patterns of innervation of neurones in the inferior mesenteric ganglion of the cat.
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猫肠系膜下神经节神经元的神经支配模式。
DOI：
10.1113/jphysiol.1983.sp014940
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Szurszewski,JH
中科院分区：
文献类型：
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作者：
Julé,Y;Krier,J;Szurszewski,JH
采用细胞内记录技术，在体外研究了猫肠系膜下神经节中非自发、不规则放电和规则放电神经元的外周和中枢突触输入模式。所有这三种类型的神经元在头和尾叶接受中枢突触输入主要来自L3和L4脊髓节段。由于不规则放电神经元接受来自节内规则放电神经元的突触输入，因此对不规则放电神经元的一些中枢输入可能已经通过规则放电神经元中继。在神经节的喙叶中，超过70%的非自发和不规则放电神经元接受来自腰结肠、肠系膜间和左右腹下神经的外周突触输入。大多数的定期放电神经元测试收到来自肠系膜和腰结肠神经的突触输入;没有定期放电神经元收到来自腹下神经的突触输入。从腰结肠神经和肠系膜间神经到不规则放电神经元的外周突触输入可能通过规则放电神经元传递。位于头叶的非自发和不规则放电神经元的轴突仅在腰结肠神经中行进到外周。在刺激任何主要的周围神经干期间，在规则放电神经元中未观察到逆向反应。这表明这些神经元是神经节内的。在尾叶，不规则放电的神经元接受了类似的模式的外周突触输入不规则放电的神经元位于喙叶。尾叶不规则放电神经元大多数通过腰结肠神经向周围投射。尾叶中的非自发神经元与位于喙叶中的神经元相反，主要从腹下神经接收外周突触输入。位于尾叶的大多数非自发神经元的轴突通过腹下神经到达外周。结果表明，非自发神经元和不规则放电神经元的头叶和大多数不规则放电神经元的尾叶处理和整合的神经命令，注定腹部内脏由腰结肠神经供应。尾叶中的非自发神经元处理和整合由腹下神经供应的预定用于盆腔内脏的神经命令。
The patterns of peripheral and central synaptic input to non‐spontaneous, irregular discharging and regular discharging neurones in the inferior mesenteric ganglion of the cat were studied in vitro using intracellular recording techniques. All three types of neurones in rostral and caudal lobes received central synaptic input primarily from L3 and L4 spinal cord segments. Since irregular discharging neurones received synaptic input from intraganglionic regular discharging neurones, some of the central input to irregular discharging neurones may have been relayed through the regular discharging neurones. In the rostral lobes of the ganglion, more than 70% of the non‐spontaneous and irregular discharging neurones tested received peripheral synaptic input from the lumbar colonic, intermesenteric and left and right hypogastric nerves. Most of the regular discharging neurones tested received synaptic input from the intermesenteric and lumbar colonic nerves; none of the regular discharging neurones received synaptic input from the hypogastric nerves. Some of the peripheral synaptic input from the lumbar colonic and intermesenteric nerves to irregular discharging neurones may have been relayed through the regular discharging neurones. Axons of non‐spontaneous and irregular discharging neurones located in the rostral lobes travelled to the periphery exclusively in the lumbar colonic nerves. Antidromic responses were not observed in regular discharging neurones during stimulation of any of the major peripheral nerve trunks. This suggests these neurones were intraganglionic. In the caudal lobes, irregular discharging neurones received a similar pattern of peripheral synaptic input as did irregular discharging neurones located in the rostral lobes. The majority of irregular discharging neurones in the caudal lobes projected their axons to the periphery through the lumbar colonic nerves. Non‐spontaneous neurones in the caudal lobes, in contrast to those located in the rostral lobes, received peripheral synaptic input primarily from the hypogastric nerves. Axons of the majority of non‐spontaneous neurones located in the caudal lobes travelled to the periphery through hypogastric nerves. The results suggest that non‐spontaneous neurones and irregular discharging neurones in the rostral lobes and the majority of irregular discharging neurones in the caudal lobes transact and integrate neural commands destined for abdominal viscera supplied by the lumbar colonic nerves. Non‐spontaneous neurones in the caudal lobes transact and integrate neural commands destined for pelvic viscera supplied by the hypogastric nerves.