The impact of weight change on cardiovascular disease risk factors in young black and white adults: the CARDIA study
The impact of weight change on cardiovascular disease risk factors in young black and white adults: the CARDIA study
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DOI：
10.1038/sj.ijo.0802243
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发表时间：
2003-03-01
影响因子：
4.9
通讯作者：
West, DS
中科院分区：
文献类型：
--
作者：
Norman, JE;Bild, D;West, DS
OBJECTIVE: To quantify the relation between weight change and change in blood pressure, lipids and insulin levels, and determine if this relation differs by race or initial level of obesity.DESIGN: Longitudinal cohort study.SETTING AND PARTICIPANTS: Community-based sample of 3325 black and white men and women aged 18-30y from four centers followed for 10y. Women pregnant at baseline or 10th year exam and persons without a recorded weight at both exams were excluded. Participants whose baseline BMI was greater than or equal to25 kg/m(2) were classified as overweight. Height, weight, HDL-cholesterol (HDL-C), LDL-cholesterol (LDL-C), fasting triglycerides, fasting insulin, and blood pressure were measured at baseline and Year 10.RESULTS: The mean (s.d.) of weight gained over 10y was 10.5 (10.0) kg (black men), 11.7 (11.0) (black women), 7.7 (8.0) (white men), and 7.2 (10.0) (white women). An increase in weight was associated with adverse changes in all factors in all race-sex groups. For example, a 9.1 kg (20-lb) weight increase in persons not overweight at baseline predicted an increase in LDL-C ranging from 0.23 mmol/l in black women to 0.28 mmol/l in black men and a decrease in HDL-C from 0.09 mmol/l (white women) to 0.11 mmol/l (white men) (all P
