Toxicity of hiba oil constituents and spray formulations to American house dust mites and copramites
Toxicity of hiba oil constituents and spray formulations to American house dust mites and copramites
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DOI：
10.1002/ps.3843
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发表时间：
2015-05-01
影响因子：
4.1
通讯作者：
Ahn, Young-Joon
中科院分区：
文献类型：
--
作者：
Kim, Jun-Ran;Perumalsamy, Haribalan;Ahn, Young-Joon
背景粉尘螨和腐食酪虫被认为是重要的过敏原来源。对海巴的毒性进行了评价。结果在接触+熏蒸剂致死试验中，(-)-三七对粉尘螨和腐烂毛滴虫的毒力最强(24hLC50分别为9.82和10.92亩GCM(-2))，与苯甲酸苄酯(9.33和10.14 MU GCM(-2))的毒力相近。香芹酚、(+)-松油烯-4-醇、-胡黄素、(-)-松油烯-4-醇、雪松油醇和松油醇对两种螨类的毒力均大于N，N-二乙基-3-甲基苯甲酰胺(LC_(50)分别为35.53和38.42mU·GCM(-2)。Hiba油30gL(-1)喷雾和市售氯氰菊酯(顺式：反式25：75)2.5gL(-1)喷雾处理对这两种螨类的死亡率分别为100%和11%。在气相致死试验中，两种化合物在密闭容器中的毒性一直高于敞开容器，表明毒性主要是通过蒸汽的作用实现的。结论室内环境中合理的防治螨类可以通过含有30gL(-1)Hiba油作为潜在接触作用熏蒸剂的喷雾配方来实现。(C)2014年化学工业学会
BACKGROUNDDermatophagoides farinae and Tyrophagus putrescentiae are recognised as an important source of allergens. An assessment was made of the toxicity of hiba, Thujopsis dolabrata var. hondai, oil and 13 organic compounds and the control efficacy of four experimental spray formulations containing the oil (5-30gL(-1) spray) against both mite species.RESULTSIn a contact+fumigant mortality bioassay, (-)-thujopsene was the most toxic constituent against D. farinae and T. putrescentiae (24h LC50 9.82 and 10.92 mu gcm(-2)), and the toxicity of the compound was nearly identical to that of benzyl benzoate (9.33 and 10.14 mu gcm(-2)). The toxicity was more pronounced in carvacrol, (+)-terpinen-4-ol, -thujaplicin, (-)-terpinen-4-ol, cedrol and -terpineol (LC50 12.05-15.20 and 12.74-16.48 mu gcm(-2)) than in N,N-diethyl-3-methylbenzamide (LC50 35.53 and 38.42 mu gcm(-2)) against both mite species. The hiba oil 30gL(-1) spray and commercial permethrin (cis:trans 25:75) 2.5gL(-1) spray treatment resulted in 100 and 11% mortality against the two mite species respectively. In vapour-phase mortality tests, the two compounds were consistently more toxic in closed versus open containers, indicating that toxicity was achieved mainly through the action of vapour.CONCLUSIONReasonable mite control in indoor environments can be achieved by a spray formulation containing the 30gL(-1) hiba oil as a potential contact-action fumigant. (c) 2014 Society of Chemical Industry