Age-dependent changes in axonal transport and cellular distribution of Tau 1 in the rat basal forebrain neurons
Age-dependent changes in axonal transport and cellular distribution of Tau 1 in the rat basal forebrain neurons
复制标题
大鼠基底前脑神经元轴突运输和 Tau 1 细胞分布的年龄依赖性变化
DOI：
10.1097/00001756-200309150-00009
复制
发表时间：
2003
期刊：
影响因子：
1.7
通讯作者：
M. Baksalerska
中科院分区：
文献类型：
--
作者：
G. Niewiadomska;M. Baksalerska
Basal forebrain (BF) cholinergic neurons are prone to degeneration due to age-dependent impairment of uptake and retrograde axonal transport of NGF. Modification and intracellular redistribution of cytoskeletal tau proteins could be responsible for this process. In this study we injected fluorogold (FG) into neocortex and hippocampus of young and aged rats. The number of neurons retro-gradely labeled with FG in subdivisions of BF was significantly lower in aged rats than in young ones. We also characterized the distribution of Tau 1 in cellular compartments of BF and hippocampal neurons. Tau 1 immunostaining restricted to neuritic structures was observed in neurons of septo-hippocampal pathways in young rats. In contrast, aged rats displayed the presence of Tau 1 isoform mainly in the somatodendritic compartment of BF neurons. The findings demonstrate that in aged rats reduced retrograde labeling of BF neurons coincide with lower expression of cholinergic markers and is accompanied by altered cellular distribution of Tau 1.
成年灵长类动物大脑的基因治疗：通过基因改造产生神经生长因子的细胞实质内移植物可预防胆碱能神经元变性。
DOI：
--
发表时间：
1996
期刊：
Gene therapy.
影响因子：
--
作者：
Tuszynski,MH;Roberts,J;Senut,MC;U,HS;Gage,FH
通讯作者：
Gage,FH