Glomerular function in neonates.
Glomerular function in neonates.
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新生儿肾小球功能。
DOI：
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发表时间：
2012
影响因子：
1.3
通讯作者：
Sara Hoseini
中科院分区：
文献类型：
--
作者：
R. Hoseini;H. Otukesh;N. Rahimzadeh;Sara Hoseini
胎儿和新生儿的肾小球滤过率较低。出生后增加，足月和早产新生儿在1月龄时达到约20 mL/min/1.73 m2。各种方法已被用于测量新生儿肾小球滤过率，如菊粉清除率、肌酐清除率和血清胱抑素C。血清肌酐浓度受多种因素影响。建议使用随时间推移稳定且不受肌肉质量或肾小管重吸收和分泌影响的其他标志物。半胱氨酸蛋白酶抑制剂C结合了这些特征;然而，在使用半胱氨酸蛋白酶抑制剂C作为新生儿肾功能的标志物时存在一些其他限制。此外，关注新生儿使用胱抑素C的研究数量有限。需要进一步研究以确定胱抑素C的正常范围水平，并调查胱抑素C是否可以取代其他测试，如血清肌酐作为新生儿肾功能的标志物。对新生儿进行新的肾功能检查也是必要的。
Glomerular filtration rate is low in fetal and neonatal life. It increases after birth and reaches approximately 20 mL/min/1.73 m2 at 1 month of age in term and preterm neonates. Various methods have been used to measure glomerular filtration rate in neonates such as inulin clearance, creatinine clearance, and serum cystatin C. Serum creatinine concentrations are influenced by many factors. It is suggested to use other markers which are stable over time and are not affected by muscle mass or tubular reabsorption and secretion. Cystatin C incorporates these characteristics; however, there are some other limitations in the use of cystatin C as a marker of kidney function in neonates. Additionally, the numbers of studies focused on the use of cystatin C in neonates is limited. There is a need for further studies to determine cystatin C's normal range levels and investigate whether cystatin C can replace other tests such as serum creatinine as marker of kidney function in newborn babies. Assessment of newer kidney function tests is also warranted in newborn infants.
影响因子：
19.6
作者：
Knight, EL;Verhave, JC;De Jong, PE
通讯作者：
De Jong, PE
影响因子：
19.6
作者：
Schwartz, G. J.;Furth, S.;Munoz, A.
通讯作者：
Munoz, A.