Pregnancy-induced Progression of Keratoconus
Pregnancy-induced Progression of Keratoconus
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DOI：
10.1097/ico.0b013e3182068adc
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发表时间：
2011-09-01
期刊：
影响因子：
2.8
通讯作者：
Ozturk, Sertac
中科院分区：
文献类型：
--
作者：
Bilgihan, Kamil;Hondur, Ahmet;Ozturk, Sertac
目的：目的：报告妊娠期圆锥角膜进展的病例。方法：对4例妊娠期圆锥角膜进展患者的7只眼进行分析。患者的平均年龄和平均随访时间分别为29.3年和39个月。进行性圆锥角膜记录了屈光、角膜地形图和硬性透气性透镜配型的变化。患者伴随系统和眼部疾病与圆锥角膜，不受控制的特应性疾病，眼睛摩擦excluded.Results：平均增加等效球镜屈光度和模拟角膜曲率值分别为1.4 +/- 1.1和1.1 +/- 0.8屈光度。在戴刚性透气性镜片的眼睛，增加在角膜顶端触摸和最佳拟合接触透镜的基弧半径减少observed.Conclusions：怀孕期间的激素变化可能会影响角膜生物力学的负面影响，怀孕可能是一个以前未被认识到的危险因素圆锥角膜的进展。据我们所知，这是第一个研究表明妊娠诱导的圆锥角膜进展的患者没有伴随疾病。
Purpose: To report eyes with keratoconus that progressed during pregnancy.Methods: Seven eyes of 4 patients with progression of keratoconus during pregnancy were included in this study. The mean age of patients and the mean follow-up duration were 29.3 years and 39 months, respectively. Progressive keratoconus was documented with changes in refraction, corneal topography, and rigid gas-permeable lens fitting pattern. Patients with accompanying systemic and ocular diseases associated with keratoconus, uncontrolled atopic disease, and eye rubbing were excluded.Results: Mean increase in spherical equivalent refraction and simulated keratometry values were 1.4 +/- 1.1 and 1.1 +/- 0.8 diopters, respectively. In eyes wearing rigid gas-permeable lenses, increase in corneal apical touch and decrease in the base curve radius of the best-fitting contact lens were observed.Conclusions: Hormonal changes during pregnancy may affect corneal biomechanics negatively, and pregnancy may be a previously unrecognized risk factor for progression of keratoconus. To our knowledge, this is the first study showing pregnancy-induced keratoconus progression in patients with no accompanying disease.