Cardiac fibroblasts: from origin to injury.
Cardiac fibroblasts: from origin to injury.
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DOI：
10.1016/j.cophys.2017.08.002
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发表时间：
2018-03
影响因子：
2.5
通讯作者：
Tallquist MD
中科院分区：
文献类型：
--
作者：
Tallquist MD
心脏成纤维细胞在细胞外基质的产生和维持中起着重要作用。虽然心脏成纤维细胞在不良适应性心肌重构中的作用一直是许多研究的焦点，但作为心脏生理学的贡献者和治疗靶点，心脏成纤维细胞已成为人们非常感兴趣的话题。最近的报告正在改变我们看待和研究心脏成纤维细胞的方式，通过使用成纤维细胞鉴定和操作的改进技术提供对成纤维细胞生物学的更多见解。在这里，我们简要总结一下最近的一些基本发现。
The cardiac fibroblast has essential roles in production and maintenance of extracellular matrix. While its role in maladaptive myocardial remodeling has been a focus of many studies, the cardiac fibroblast has become a topic of great interest as a contributor to heart physiology and as a therapeutic target. Recent reports are changing how we view and study the cardiac fibroblast by providing greater insights into fibroblast biology using refined techniques for fibroblast identification and manipulation. Here, we briefly summarize some of these fundamental recent findings.