A model predictive control based scheduling method for HIV therapy
A model predictive control based scheduling method for HIV therapy
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DOI：
10.1016/j.jtbi.2005.05.004
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发表时间：
2006-01-21
影响因子：
2
通讯作者：
Teel, AR
中科院分区：
文献类型：
--
作者：
Zurakowski, R;Teel, AR
最近开发的人类免疫系统和人类免疫缺陷病毒（HIV）的相互作用的模型表明，使用高活性抗逆转录病毒治疗（HAART）的中断，以模拟治疗性疫苗和诱导细胞毒性淋巴细胞（CTL）介导的HIV感染的控制的可能性。我们已经开发了一种基于模型预测控制（MPC）的方法，用于确定最佳的治疗中断时间表。该方法提供了一个临床上可实施的框架，用于计算中断时间表，该中断时间表对由于测量和患者变化引起的错误是鲁棒的。在本文中，我们讨论了这项工作的医疗动机，介绍了基于MPC的方法，显示模拟结果，并讨论了未来的工作，实现该方法所必需的。(c)2005爱思唯尔有限公司保留所有权利。
Recently developed models of the interaction of the human immune system and the human immunodeficiency virus (HIV) suggest the possibility of using interruptions of highly active anti-retroviral therapy (HAART) to simulate a therapeutic vaccine and induce cytotoxic lymphocyte (CTL) mediated control of HIV infection. We have developed a model predictive control (MPC) based method for determining optimal treatment interruption schedules for this purpose. This method provides a clinically implementable framework for calculating interruption schedules that are robust to errors due to measurement and patient variations. In this paper, we discuss the medical motivation for this work, introduce the MPC-based method, show simulation results, and discuss future work necessary to implement the method. (c) 2005 Elsevier Ltd. All rights reserved.