Ponicidin and oridonin are responsible for the antiangiogenic activity of Rabdosia rubescens, a constituent of the herbal supplement PCSPES
Ponicidin and oridonin are responsible for the antiangiogenic activity of Rabdosia rubescens, a constituent of the herbal supplement PCSPES
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DOI：
10.1021/np0304114
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发表时间：
2004-01-01
影响因子：
5.1
通讯作者：
Gunatilaka, AAL
中科院分区：
文献类型：
--
作者：
Meade-Tollin, LC;Wijeratne, EMK;Gunatilaka, AAL
抗血管生成活性已被确定在水性乙醇提取物的Rabdosia rubescens，一个组成部分的膳食补充剂PC SPES。使用一种新的基于体外人内皮细胞的血管生成测定法进行生物测定指导的分级分离，得到了二萜类化合物ponicidin（1）和oridonin（2），在亚细胞毒性浓度下具有显著的抗血管生成活性，表明这些成分可能对PC SPES作为晚期前列腺癌治疗药物的临床疗效有很大贡献。
Antiangiogenic activity has been identified in an aqueous EtOH extract of Rabdosia rubescens, a component of the dietary supplement PC SPES. Bioassay-guided fractionation using a novel in vitro human endothelial cell-based assay for angiogenesis afforded the diterpenoids ponicidin (1) and oridonin (2), with significant antiangiogenic activity at sub-cytotoxic concentrations, suggesting that these constituents may strongly contribute to the demonstrated clinical efficacy of PC SPES as a treatment for advanced prostate cancer.