Serum irisin levels in new-onset type 2 diabetes
Serum irisin levels in new-onset type 2 diabetes
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DOI：
10.1016/j.diabres.2013.01.007
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发表时间：
2013-04-01
影响因子：
5.1
通讯作者：
Park, Keun-Gyu
中科院分区：
文献类型：
--
作者：
Choi, Yeon-Kyung;Kim, Mi-Kyung;Park, Keun-Gyu
目的：Irisin已被鉴定为一种新型肌因子，其驱动白色脂肪组织的棕色脂肪样转化。在这项横断面研究中，我们调查了血清鸢尾素水平是否降低2型糖尿病（T2 D）患者与正常葡萄糖耐量（NGT）的对照组相比，并评估血清鸢尾素水平和各种代谢参数之间的关联。方法：研究人群是从一项以人群为基础的研究，包括104例NGT和104例新发T2 D。测定血清鸢尾素和脂联素水平及代谢指标。结果：与NGT对照组相比，初发T2 D组血清Irisin水平显著降低（p = 0.003），而NGT对照组血清Irisin水平显著降低（p = 0.003）。在针对各种代谢参数调整的多变量模型中，鸢尾素水平升高与新诊断T2 D的患病几率降低（OR 0.64，95%CI 0.47-0.88，p = 0.006）相关。多元回归分析显示，2 h血糖是影响血清鸢尾素水平的独立变量（p = 0.004）。结论：T2 D患者血清鸢尾素水平降低，且与初诊T2 D呈负相关，提示鸢尾素可能在糖耐量异常和T2 D中起重要作用。(C)2013爱思唯尔爱尔兰有限公司版权所有。
Aims: Irisin has been identified as a novel myokine that drives brown-fat-like conversion of white adipose tissue. In this cross-sectional study, we investigated whether serum irisin levels are decreased in patients with type 2 diabetes (T2D) compared with control subjects with normal glucose tolerance (NGT), and assessed the association between serum irisin levels and various metabolic parameters.Methods: The study population was selected from a population-based study and included 104 subjects with NGT and 104 subjects with new-onset T2D. Serum irisin and adiponectin levels and metabolic parameters were measured. Multivariate logistic regression analysis was performed to assess the association between irisin levels and newly diagnosed T2D.Results: Serum irisin levels were significantly decreased in the new-onset T2D group compared with the NGT control group (p = 0.003). In a multivariable model adjusted for various metabolic parameters, increased irisin levels were associated with reduced odds (OR 0.64, 95% CI 0.47-0.88, p = 0.006) of prevalent newly diagnosed T2D. Furthermore, multiple regression analysis showed that 2 h plasma glucose was an independent variable influencing serum irisin levels (p = 0.004).Conclusion: In the present study, we found that serum irisin levels were decreased in T2D patients and inversely associated with newly diagnosed T2D, suggesting that irisin may play a crucial role in glucose intolerance and T2D. (C) 2013 Elsevier Ireland Ltd. All rights reserved.