The C-reactive Protein to Albumin Ratio Predicts Long-Term Outcomes in Patients with Pancreatic Cancer After Pancreatic Resection
The C-reactive Protein to Albumin Ratio Predicts Long-Term Outcomes in Patients with Pancreatic Cancer After Pancreatic Resection
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DOI：
10.1007/s00268-016-3491-4
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发表时间：
2016-09-01
影响因子：
2.6
通讯作者：
Yanaga, Katsuhiko
中科院分区：
文献类型：
--
作者：
Haruki, Koichiro;Shiba, Hiroaki;Yanaga, Katsuhiko
C反应蛋白与白蛋白（CRP/Alb）比值是一种新的基于炎症的预后评分，与脓毒症患者的预后相关。CRP/Alb比值在癌症患者中的预后价值尚未确定。本研究的目的是评估CRP/Alb比值在胰腺切除术后胰腺癌治疗结果的意义。结果CRP/Alb比值的最佳临界值为0.03。对于无病生存率，术前胆管引流（p = 0.011），晚期肿瘤淋巴结转移（TNM）分类（p = 0.002），高CRP/Alb比值（p = 0.049）的单变量分析，和先进的TNM分类（p = 0.003）的多变量分析，是癌症复发的独立和重要的预测因子。对于总生存率，术前胆道引流（p = 0.012），晚期TNM分级（p = 0.001），CRP/Alb比值较高（p = 0.023）通过单变量分析和高级TNM分类（p = 0.003）和较高的CRP/Alb比值（p = 0.035）通过多变量分析，结论CRP/Alb比值可能是长期预后不良的一个独立和重要的指标，胰腺癌患者胰腺切除术后的长期结局。
Background The C-reactive protein to albumin (CRP/Alb) ratio, a novel inflammation-based prognostic score, is associated with outcomes in septic patients. The prognostic value of CRP/Alb ratio has not been established in cancer patients. The aim of this study is to evaluate the significance of CRP/Alb ratio in therapeutic outcome after pancreatic resection for pancreatic cancer.Methods The study comprised 113 patients who had undergone pancreatic resection for pancreatic cancer between April 2001 and December 2011. We retrospectively investigated the relation between CRP/Alb ratio and disease-free as well as overall survival.Results The optimal cut-off level of the CRP/Alb ratio was 0.03. For disease-free survival, preoperative biliary drainage (p = 0.011), advanced tumor-node-metastasis (TNM) classification (p = 0.002), and higher CRP/Alb ratio (p = 0.049) by univariate analysis, and advanced TNM classification (p = 0.003) by multivariate analysis, were independent and significant predictors of cancer recurrence. For overall survival, preoperative biliary drainage (p = 0.012), advanced TNM classification (p = 0.001), and higher CRP/Alb ratio (p = 0.023) by univariate analysis, and advanced TNM classification (p = 0.003) and higher CRP/Alb ratio (p = 0.035) by multivariate analysis, were independent and significant predictors of poor patient outcome.Conclusions The CRP/Alb ratio may be an independent and significant indicator of poor long-term outcomes in patients with pancreatic cancer after pancreatic resection.