Alteration of leptin-induced STAT3 activation in the brain of senescence-accelerated mouse (SAM) P8
Alteration of leptin-induced STAT3 activation in the brain of senescence-accelerated mouse (SAM) P8
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DOI：
10.1248/bpb.28.1514
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发表时间：
2005-08-01
影响因子：
2
通讯作者：
Nomura, Y
中科院分区：
文献类型：
--
作者：
Hosoi, T;Okuma, Y;Nomura, Y
我们使用衰老加速小鼠倾向8（SAMP 8），一个有用的加速衰老模型，研究瘦素与衰老的反应。在SAMP 8中发现瘦素诱导的下丘脑中STAT 3磷酸化的状态高于SAMR 1，SAMR 1是显示正常衰老的对照小鼠，在14-18个月大时，但在2个月大时不是。此外，瘦素受体Ob-Rb在下丘脑的表达上调SAMP 8。结果表明，瘦素敏感性随着SAM小鼠大脑中的衰老而增加。
We used senescence-accelerated mouse prone 8 (SAMP8), a useful model of accelerated aging, to investigate the responsiveness to leptin with aging. The state of leptin-induced STAT3 phosphorylation in the hypothalamus was found to be higher in SAMP8 than in SAMR1, a control mouse showing normal aging, at 14-18 months of age but not at 2 months of age. Moreover, leptin receptor Ob-Rb expression in the hypothalamus was up-regulated in SAMP8. The results indicate that leptin sensitivity increases with aging in the SAM mouse brain.