miR-92a is upregulated in cervical cancer and promotes cell proliferation and invasion by targeting FBXW7
miR-92a is upregulated in cervical cancer and promotes cell proliferation and invasion by targeting FBXW7
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miR-92a在宫颈癌中上调并通过靶向FBXW7促进细胞增殖和侵袭
DOI：
10.1016/j.bbrc.2015.01.066
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发表时间：
2015-02-27
影响因子：
3.1
通讯作者：
Yu, Huizhi
中科院分区：
文献类型：
--
作者：
Zhou, Chuanyi;Shen, Liangfang;Yu, Huizhi
MicroRNAs (miRNAs) are involved in the cervical carcinogenesis and progression. In this study, we investigated the role of miR-92a in progression and invasion of cervical cancer. MiR-92a was significantly upregulated in cervical cancer tissues and cell lines. Overexpression of miR-92a led to remarkably enhanced proliferation by promoting cell cycle transition from G1 to S phase and significantly enhanced invasion of cervical cancer cells, while its knockdown significantly reversed these cellular events. Bioinformatics analysis suggested F-box and WD repeat domain-containing 7 (FBXW7) as a novel target of miR-92a, and miR-92a suppressed the expression level of FBXW7 mRNA by direct binding to its 3'-un-translated region (3'UTR). Expression of miR-92a was negatively correlated with FBXW7 in cervical cancer tissues. Furthermore, Silencing of FBXW7 counteracted the effects of miR-92a suppression, while its overexpression reversed oncogenic effects of miR-92a. Together, these findings indicate that miR-92a acts as an onco-miRNA and may contribute to the progression and invasion of cervical cancer, suggesting miR-92a as a potential novel diagnostic and therapeutic target of cervical cancer. (C) 2015 Elsevier Inc. All rights reserved.
