Blood pressure and urinary sodium excretion in relation to 16 genetic polymorphisms in the natriuretic peptide system in Chinese
Blood pressure and urinary sodium excretion in relation to 16 genetic polymorphisms in the natriuretic peptide system in Chinese
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中国人血压和尿钠排泄与利尿钠肽系统16个基因多态性的关系
DOI：
10.1507/endocrj.ej14-0104
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发表时间：
2014-09-20
影响因子：
2
通讯作者：
Wang, Ji-Guang
中科院分区：
文献类型：
--
作者：
Hu, Bang-Chuan;Li, Yan;Wang, Ji-Guang
我们系统地研究了中国人群中利钠肽系统（NPPA、NPPB、NPPC、NPRA、NPRC和Corin基因）的单核苷酸多态性（snp）与血压的关系。研究人群于2003年至2009年从上海以南500公里的山区招募。使用ABI SNapShot方法，我们首先对2005年入组的951名受试者进行了16个snp的基因分型，然后对从最初研究中选择的5个snp进行了验证，剩余的1355名受试者进行了基因分型。总体而言，所研究的遗传多态性与血压和尿中阳离子排泄的相关性较弱或不显著。然而，在初步研究中，rs198358多态性与舒张压相关的年龄之间存在显著（P-int=0.003）相互作用。校正协变量后，176名60岁及以上受试者中G等位基因携带者的舒张压明显高于AA纯合子（77.8 +/- 1.72 vs 73.9 +/- 1.54 mmHg， P=0.001）。在初步联合验证研究中，这种相互作用仍然具有统计学意义（P-int=0.02）。所有受试者携带G等位基因与AA纯合子患高血压的比值比为1.25 (95% CI: 1.03-1.52； P=0.03)， 40岁以下、40-59岁和60岁及以上受试者的比值比分别为0.85 （0.51-1.41；P=0.53）、1.30 （0.98-1.73；P=0.06）和1.45 （0.95-2.22；P=0.08）。利钠肽系统的一些遗传多态性可能与血压有关。然而，随着年龄的增长，这种关联不仅大小，而且方向也可能发生变化。
We systematically investigated the association between single nucleotide polymorphisms (SNPs) in the natriuretic peptide system (NPPA, NPPB, NPPC, NPRA, NPRC, and Corin genes) and blood pressure in a Chinese population. The study population was recruited from a mountainous area 500 km south of Shanghai from 2003 to 2009. Using the ABI SNapShot method, we first genotyped 951 subjects enrolled in 2005 for 16 SNPs and then the remaining 1355 subjects as validation for 5 SNPs selected from the primary study. Overall, the association of the studied genetic polymorphisms with blood pressure and urinary excretion of cations was weak or non-significant. However, in the primary study, there was significant (P-int=0.003) interaction between the rs198358 polymorphism and age in relation to diastolic blood pressure. After adjustment for covariates, diastolic blood pressure was significantly higher in the G allele carriers than AA homozygotes in 176 subjects aged 60 years or older (77.8 +/- 1.72 vs 73.9 +/- 1.54 mmHg, P=0.001). In the primary combined with validation studies, this interaction remained statistically significant (P-int=0.02). The odds ratio of hypertension for carrying the G allele versus AA homozygotes was 1.25 (95% CI: 1.03-1.52; P=0.03) in all subjects, and 0.85 (0.51-1.41; P=0.53), 1.30 (0.98-1.73; P=0.06), and 1.45 (0.95-2.22; P=0.08) in the subjects younger than 40 years, 40-59 years, and 60 years or older, respectively. Some of the genetic polymorphisms in the natriuretic peptide system might be associated with blood pressure. However, not only the size, but also the direction of the association may change with age.