Large gain in translational entropy of water is a major driving force in protein folding
Large gain in translational entropy of water is a major driving force in protein folding
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DOI：
10.1016/j.cplett.2004.09.140
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发表时间：
2004-12-01
影响因子：
2.8
通讯作者：
Kinoshita, M
中科院分区：
文献类型：
--
作者：
Harano, Y;Kinoshita, M
在蛋白质折叠的早期研究中缺乏的观点是，这个过程受到水分子热运动的严重影响。在这里，它指出，有一个强大的驱动力，在平移熵（TE）的水，这与构象熵的大损失的折叠竞争的大增益。我们分析了TE的水，其中一个蛋白质分子与规定的构象浸泡。我们考虑了一些构象，并表明，最大的TE仅在本机结构中实现。(C)2004 Elsevier B.V.保留所有权利。
A view lacking in earlier studies on protein folding is that the process is critically influenced by the thermal motion of water molecules. Here it is pointed out that there is a powerful driving force, a large gain in the translational entropy (TE) of water, which competes with the large loss of the conformational entropy in the folding. We analyze the TE of water in which a protein molecule with a prescribed conformation is immersed. We consider a number of conformations and show that the largest TE is attained only in the native structure. (C) 2004 Elsevier B.V. All rights reserved.