Importance of inhibitor of DNA binding/differentiation 2 in hepatic stellate cell differentiation and proliferation
Importance of inhibitor of DNA binding/differentiation 2 in hepatic stellate cell differentiation and proliferation
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DOI：
10.1111/j.1872-034x.2007.00089.x
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发表时间：
2007-08
影响因子：
4.2
通讯作者：
Kunihiko Tajima;S. Terai;T. Takami;Kotaro Kawaguchi;K. Okita;I. Sakaida
中科院分区：
文献类型：
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作者：
Kunihiko Tajima;S. Terai;T. Takami;Kotaro Kawaguchi;K. Okita;I. Sakaida
背景/目的：在肝纤维化中，活化的肝星状细胞（HSC）转化为肌成纤维细胞。抑制环螺旋（HLH）转录因子如MyoD调节肌细胞的分化，DNA结合/分化抑制因子（Id）家族包括显性负性HLH转录调节因子，其抑制分化并促进细胞增殖。在本研究中，我们研究了Id家族蛋白如何调节HSC。
Background/Aim: In liver fibrosis, activated hepatic stellate cells (HSC) are transformed into myofibroblasts. Helix‐loop‐helix (HLH) transcriptional factors such as MyoD regulate the differentiation of myocytes, and the inhibitor of DNA binding/differentiation (Id) family comprises dominant negative HLH transcriptional regulators that inhibit differentiation and promote cell proliferation. In the present study, we investigated how the Id family proteins regulate HSC.