Intestinal transplantation: Current status and future directions
Intestinal transplantation: Current status and future directions
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DOI：
10.1111/j.1440-1746.2011.06783.x
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发表时间：
2011-08-01
影响因子：
4.1
通讯作者：
Testro, Adam G.
中科院分区：
文献类型：
--
作者：
Garg, Mayur;Jones, Robert M.;Testro, Adam G.
在人类首次进行肠道移植手术30年后，这种挽救生命的手术已经成熟，现在为一小群患有危及生命的肠道衰竭和肠外营养并发症的患者提供了长期生存的希望。成功率大大提高，主要是由于免疫抑制方案的进步，手术技术和术后护理的改进以及经验的积累。肠移植受者的管理需要仔细监测、预防和治疗排斥反应和感染，以及优化喂养和营养。通过这种方法，生存率和生活质量明显提高，因此肠移植现在是这一高度复杂的患者群体的一种确定和接受的手术。
Three decades after the first intestinal transplant was performed in humans, this life-saving procedure has come of age and now offers hope of long-term survival in a small group of patients with life-threatening complications of intestinal failure and parenteral nutrition. Success rates have greatly improved, largely through advances in immunosuppression protocols, improved surgical technique and postoperative care, and accumulated experience. Management of the intestinal transplant recipient entails careful surveillance, prevention, and treatment of rejection and infection, as well as optimization of feeding and nutrition. With this approach, survival and quality of life are demonstrably improved, such that intestinal transplantation is now an established and accepted procedure for this very select group of highly-complex patients.