MUC1, glycans and the cell-surface barrier to embryo implantation
MUC1, glycans and the cell-surface barrier to embryo implantation
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DOI：
10.1042/0300-5127:0290153
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发表时间：
2001-05-01
影响因子：
3.9
通讯作者：
Jones, CJP
中科院分区：
文献类型：
--
作者：
Aplin, JD;Meseguer, M;Jones, CJP
当它接近母体表面时，附着的胚胎遇到含有粘蛋白MUC1的上皮糖萼。细胞表面高密度的MUC1可以抑制细胞粘附。这增加了子宫屏障存在的可能性，这可能会导致母亲排斥质量较差的胚胎。为了研究胚胎着床的机制，我们用子宫内膜上皮单层培养人胚胎。发现孵出的囊胚很容易附着在上皮表面。MUC1在附着胚胎下方和附近的上皮细胞中缺失，而在邻近细胞中正常表达。
As it approaches the maternal surface, the attaching embryo encounters the epithelial glycocalyx, which contains the mucin, MUC1. A high density of MUC1 at the cell surface can inhibit cell adhesion. This raises the possibility of the existence of a uterine barrier to implantation that might allow maternal rejection of poorer quality embryos. To investigate the mechanism of implantation, human embryos were incubated with endometrial epithelial monolayers. Hatched blastocysts were found to attach readily to the epithelial surface. MUC1 was lost from epithelial cells beneath and near to the attached embryo, while normal expression persisted in neighbouring cells.