CARDIAC NOREPINEPHRINE STORES IN EXPERIMENTAL HEART FAILURE IN DOG
CARDIAC NOREPINEPHRINE STORES IN EXPERIMENTAL HEART FAILURE IN DOG
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DOI：
10.1172/jci105113
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发表时间：
1964-01-01
影响因子：
15.9
通讯作者：
BRAUNWALD, E
中科院分区：
文献类型：
--
作者：
CHIDSEY, CA;KAISER, GA;BRAUNWALD, E
最近观察到充血性心力衰竭患者的心肌去甲肾上腺素浓度降低，提示在这种情况下可能发生神经递质储存的消耗。这种可能性在8只狗的实验性充血性心力衰竭中得到了检验，这是由三尖瓣不全和肺动脉狭窄造成的。6 ~ 8周后处死，所有动物均出现腹水和肝充血。两个心室去甲肾上腺素的浓度和总量显著降低，右心室和左心室平均每公斤体重分别为0.15和0.63 [mu]g，而对照组为1.14和3.89 [mu]g / kg。尽管心室去甲肾上腺素的耗竭，但在心力衰竭的动物中，放射性去甲肾上腺素的摄取和示踪剂的结合并没有显著减少。本文研究了酪胺在离体右心室乳头肌制剂中的作用。在正常狗的肌肉中酪胺产生的最大收缩力平均比对照组高138%，而在心力衰竭狗的肌肉中不到20%。由此可见，在充血性心力衰竭时，去甲肾上腺素储存会发生耗竭，这种耗竭可能会干扰交感神经冲动向心脏的传递，从而对心肌性能产生不利影响。
The recent observation that myocardial norepinephrine concentration is reduced in patients withcongestive heart failure suggested that a depletion of neurotransmitter store may occur in this condition. This possibility was examined in experimental congestive heart failure, which was produced in 8 dogs by creation of tricuspid insufficiency and pulmonic stenosis. When killed 6 to 8 weeks later, ascites and hepatic congestion were present in all animals. The concentration and total amount of norepinephrine in both ventricles was strikingly reduced, the latter averaging 0.15 and 0.63 [mu]g per kg body weight, respectively, in right and left ventricles, compared to 1.14 and 3.89 [mu]g per kg in control dogs. In spite of this depletion of ventricular norepinephrine, uptake and binding of a tracer dose of radioactive norepinephrine was not significantly reduced in the animals with heart failure. The effects of tyramine were studied in isolated right ventricular papillary muscle preparations. The maximal increase in contractile force produced by tyramine averaged 138% above control in muscles from normal dogs and less than 20% in muscles from dogs with heart failure. It is concluded that depletion of norepinephrine stores occurs in congestive heart failure, and it is suggested that this depletion may interfere with transmission of sympathetic nerve impulses to the heart and thereby adversely affect myocardial performance.