Hippocampus-dependent learning promotes survival of new neurons in the dentate gyrus at a specific time during cell maturation
Hippocampus-dependent learning promotes survival of new neurons in the dentate gyrus at a specific time during cell maturation
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DOI：
10.1016/j.neuroscience.2007.07.046
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发表时间：
2007-10-26
期刊：
影响因子：
3.3
通讯作者：
Galea, L. A. M.
中科院分区：
文献类型：
--
作者：
Epp, J. R.;Spritzer, M. D.;Galea, L. A. M.
成年海马区的神经发生贯穿一生，并可能在海马区依赖的学习和记忆中发挥重要作用。以前的研究一直是模棱两可的，表明空间学习可能会增强、减少或不会显著影响新神经元的存活。这些不同结果的一个潜在原因可能是何时给予溴脱氧尿苷(BrdU)相对于空间训练的不同。我们研究了BrdU给药和空间学习之间的时间间隔是否会改变标记细胞的存活。在第0天注射1次BrdU，然后在注射BrdU后1-5、6-10或11-15天进行标准地点版的Morris水任务训练。我们发现，只有在空间训练开始前6天给予BrdU时，才能增强海马区的神经发生。在BrdU注射后1天或11天开始训练的组，海马神经发生没有显著变化。这表明，新神经元的发育存在一个关键期，在此期间，海马体的激活可能会改变新神经元的存活率。此外，当使用中位数分裂根据整体表现将大鼠分为差学习者和好学习者时，只有差位置学习者和不好位置学习者表现出比线索学习更多的海马神经发生，并随着训练时间的推移而崩溃。这些发现进一步证明了学习和成人神经发生之间的联系。(C)2007年IBRO。爱思唯尔有限公司出版。保留所有权利。
Adult neurogenesis in the hippocampus continues throughout life and may play an important role in hippocampus-dependent learning and memory. Previous research has been equivocal, demonstrating that spatial learning may enhance, decrease or not significantly affect the survival of new neurons. A potential cause of these varying results may be differences in when bromodeoxyuridine (BrdU) was administered relative to spatial training. We examined whether the time elapsed between BrdU administration and spatial learning would alter the survival of the labeled cells. We injected rats with BrdU once on day 0 and then trained in the standard place version of the Morris water task on days 1-5, 6-10 or 11-15 after BrdU injection. We found an enhancement of neurogenesis in the hippocampus only when BrdU was administered 6 days prior to the beginning of spatial training. There was no significant change in hippocampal neurogenesis for groups that started training either 1 or 11 days following BrdU administration. This suggests that a critical period exists in the development of new neurons during which time their survival may be altered by activation of the hippocampus. Furthermore, when dividing rats into poor versus good learners based on overall performance using a median split, only poor place learners and not good place learners exhibit increased hippocampal neurogenesis compared with cue learning, collapsed across time of training. These findings provide further evidence of a link between learning and adult neurogenesis. (C) 2007 IBRO. Published by Elsevier Ltd. All rights reserved.