Lesions of the organum vasculosum of the lamina terminalis (OVLT) attenuate osmotically-induced drinking and vasopressin secretion in the dog.
Lesions of the organum vasculosum of the lamina terminalis (OVLT) attenuate osmotically-induced drinking and vasopressin secretion in the dog.
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DOI：
10.1210/endo-110-5-1837
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发表时间：
1982-05
期刊：
影响因子：
4.8
通讯作者：
T. Thrasher;L. Keil;D. Ramsay
中科院分区：
文献类型：
--
作者：
T. Thrasher;L. Keil;D. Ramsay
本实验观察了犬卵巢外淋巴管毁损前后饮水和静脉注射高渗氯化钠引起精氨酸加压素（AVP）分泌的变化。破坏OVLT后，血浆渗透压与血浆AVP之间的函数关系消失。此外，在OVLT病变犬中，诱导性饮酒显著减少。这些数据与OVLT在犬中含有β受体的假设一致。
Drinking and secretion of arginine vasopressin (AVP) in response to intravenous infusion of hypertonic NaCl were studied in dogs before and after destruction of the OVLT. The functional relationship between plasma osmolality and plasma AVP was eliminated following destruction of the OVLT. Furthermore, osmotically-induced drinking was significantly reduced in dogs with OVLT lesions. These data are compatible with the hypothesis that the OVLT contains osmoreceptors in the dog.