GenAge: a genomic and proteomic network map of human ageing
GenAge: a genomic and proteomic network map of human ageing
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DOI：
10.1016/j.febslet.2004.07.006
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发表时间：
2004-07-30
期刊：
影响因子：
3.5
通讯作者：
Toussaint, O
中科院分区：
文献类型：
--
作者：
de Magalhaes, JP;Toussaint, O
这项工作的目的是提供人类衰老的遗传学概述，以获得有关机制的新见解。通过将从模式生物到人类的发现，如小鼠中延迟或加速衰老的突变，我们构建了先前与衰老相关的基因网络：即与DNA代谢相关的网络和涉及GH/IGF-1轴的网络。收集有关这些蛋白质相互作用伙伴的数据使我们能够通过“联想内疚”的方法提出参与许多蛋白质的衰老。为了整理我们的数据，我们开发了第一个与人类衰老相关的基因数据库：GenAge。GenAge拥有超过200个条目，可作为人类衰老相关基因的参考数据库。此外，我们绘制了人类衰老的第一个蛋白质组学网络图，这表明了发育遗传学和衰老遗传学之间的关系。我们的工作可以作为一个框架，在这个框架上，系统生物学对衰老的理解可以得到发展。GenAge可免费用于学术目的：http://genomics.senescence.info/genes/。(C) 2004年由Elsevier B.V.代表欧洲生化学会联合会出版。
The aim of this work was to provide an overview of the genetics of human ageing to gain novel insights about the mechanisms involved. By incorporating findings from model organisms to humans, such as mutations that either delay or accelerate ageing in mice, we constructed the gene networks previously related to ageing: namely, the network related to DNA metabolism and the network involving the GH/IGF-1 axis. Gathering data about the interacting partners of these proteins allowed us to suggest the involvement in ageing of a number of proteins through a "guilt-by-association" methodology. To organize our data, we developed the first curated database of genes related to human ageing: GenAge. With over 200 entries, GenAge may serve as a reference database of genes related to human ageing. Moreover, we rendered the first proteomic network map of human ageing, which suggests a relationship between the genetics of development and the genetics of ageing. Our work serves as a framework upon which a systems-biology understanding of ageing can be developed. GenAge is freely available for academic purposes at: http://genomics.senescence.info/genes/. (C) 2004 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.