A machine learning methodology for the selection and classification of spontaneous spinal cord dorsum potentials allows disclosure of structured (non-random) changes in neuronal connectivity induced by nociceptive stimulation.
A machine learning methodology for the selection and classification of spontaneous spinal cord dorsum potentials allows disclosure of structured (non-random) changes in neuronal connectivity induced by nociceptive stimulation.
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DOI：
10.3389/fninf.2015.00021
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发表时间：
2015
影响因子：
3.5
通讯作者：
Rudomin P
中科院分区：
文献类型：
--
作者：
Martin M;Contreras-Hernández E;Béjar J;Esposito G;Chávez D;Glusman S;Cortés U;Rudomin P
以往的研究旨在通过预先确定的模板来选择特定类型的自发性脊髓背侧电位，以揭示参与自发脊髓背侧电位(CDPs)产生的神经网络的功能组织。由于这一过程耗时且需要持续监测，因此仅限于分析两种特定类型的CDP(负性CDP和负正性CDP)，从而排除可能反映其他假定与功能相关的神经网络激活的电位。我们现在提出了一种基于机器学习的新方法，它允许高效和无偏见地选择各种不同形状和幅度的自发CDP。通过分析麻醉猫皮内注射少量辣椒素对不同类型自发CDP产生概率的影响来评价本方法的可靠性和性能，该过程可诱导中枢敏化状态，导致痛觉过敏和痛觉过敏。用目前描述的选择方法获得的结果允许检测具有特定形状和幅度的自发CDP，这些自发CDP被认为代表对伤害性刺激反应获得不同结构的不同结构的背角神经元的功能耦合组的激活。这些变化被认为是作为体内平衡调节的一部分，倾向于将感觉信息充分传递到特定功能要求的反应。
Previous studies aimed to disclose the functional organization of the neuronal networks involved in the generation of the spontaneous cord dorsum potentials (CDPs) generated in the lumbosacral spinal segments used predetermined templates to select specific classes of spontaneous CDPs. Since this procedure was time consuming and required continuous supervision, it was limited to the analysis of two specific types of CDPs (negative CDPs and negative positive CDPs), thus excluding potentials that may reflect activation of other neuronal networks of presumed functional relevance. We now present a novel procedure based in machine learning that allows the efficient and unbiased selection of a variety of spontaneous CDPs with different shapes and amplitudes. The reliability and performance of the present method is evaluated by analyzing the effects on the probabilities of generation of different classes of spontaneous CDPs induced by the intradermic injection of small amounts of capsaicin in the anesthetized cat, a procedure known to induce a state of central sensitization leading to allodynia and hyperalgesia. The results obtained with the selection method presently described allowed detection of spontaneous CDPs with specific shapes and amplitudes that are assumed to represent the activation of functionally coupled sets of dorsal horn neurones that acquire different, structured configurations in response to nociceptive stimuli. These changes are considered as responses tending to adequate transmission of sensory information to specific functional requirements as part of homeostatic adjustments.