Radiotherapy and combination chemotherapy in advanced Ewing's Sarcoma-Intergroup study.
Radiotherapy and combination chemotherapy in advanced Ewing's Sarcoma-Intergroup study.
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晚期尤因肉瘤组间研究中的放疗和联合化疗。
DOI：
10.1002/1097-0142(19810415)47:8
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发表时间：
1981
期刊：
影响因子：
6.2
通讯作者：
Pritchard,D
中科院分区：
文献类型：
--
作者：
Pilepich,MV;Vietti,TJ;Nesbit,ME;Tefft,M;Kissane,J;Burgert,EO;Pritchard,D
44例转移性（36例患者）和晚期区域性（8例患者）尤文肉瘤患者接受了一项方案治疗，该方案对所有明显疾病部位（原发部位和转移部位）采用强化联合化疗和放疗。31名患者达到完全缓解，8名患者达到部分缓解，5名患者对治疗无反应。在31例达到完全缓解的患者中（12例有转移，6例有区域扩散），18例保持无病，中位随访时间为34个月，而9例患者发生复发。4例患者死于治疗并发症。尽管晚期复发仍有可能，但转移性尤文肉瘤的强化多模式治疗似乎可以延长无病生存期，并可能使相当大比例的患者治愈。
Forty‐four patients with metastatic (36 patients) and advanced regional (eight patients) Ewing's sarcoma were treated on a protocol employing intensive combination chemotherapy and radiotherapy to all sites of overt disease (primary site and metastatic sites). Thirty‐one patients achieved a complete remission, eight achieved a partial remission, and five patients did not respond to treatment. Of the 31 patients who achieved a complete remission (12 had metastases and six had regional spread), 18 remained disease‐free with a median follow‐up of 34 months, while recurrences occurred in nine patients. Four patients died of complications of treatment.Although late relapses can still be expected, it appears that intensive multimodal management in metastatic Ewing's sarcoma can produce prolonged disease‐free survival and possibly cure in a significant percentage of patients.