Fluid balance in critically ill children with acute lung injury
Fluid balance in critically ill children with acute lung injury
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DOI：
10.1097/ccm.0b013e31825bc54d
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发表时间：
2012-10-01
影响因子：
8.8
通讯作者：
Randolph, Adrienne G.
中科院分区：
文献类型：
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作者：
Valentine, Stacey L.;Sapru, Anil;Randolph, Adrienne G.
目的：在液体和导管治疗试验（NCT 00281268）中，随机分配至保守与自由液体管理方案的急性肺损伤成人患者的存活天数和无机械呼吸机支持天数（无呼吸机天数）增加。招募足够的急性肺损伤儿童进入儿科试验是具有挑战性的。贝叶斯统计方法依赖于成人试验的先验效应估计，需要较少的患者。准备一项反映液体和导管治疗试验的贝叶斯儿科试验，我们的目的是：1）确定液体平衡和无呼吸机天数之间的负相关性; 2）确定液体和导管治疗试验自由或保守组中液体平衡随时间的变化是否与成人更相似。设计：多中心回顾性队列研究。设置：5个儿科重症监护室。患者：机械通气儿童（年龄>= 1个月至
Objectives: In the Fluid and Catheter Treatment Trial (NCT00281268), adults with acute lung injury randomized to a conservative vs. liberal fluid management protocol had increased days alive and free of mechanical ventilator support (ventilator-free days). Recruiting sufficient children with acute lung injury into a pediatric trial is challenging. A Bayesian statistical approach relies on the adult trial for the a priori effect estimate, requiring fewer patients. Preparing for a Bayesian pediatric trial mirroring the Fluid and Catheter Treatment Trial, we aimed to: 1) identify an inverse association between fluid balance and ventilator-free days; and 2) determine if fluid balance over time is more similar to adults in the Fluid and Catheter Treatment Trial liberal or conservative arms.Design: Multicentered retrospective cohort study.Setting: Five pediatric intensive care units.Patients: Mechanically ventilated children (age >= 1 month to