Molecular mechanisms of cellular interactions in peripheral nerve regeneration
Molecular mechanisms of cellular interactions in peripheral nerve regeneration
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DOI：
10.1097/00019052-200110000-00013
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发表时间：
2001-10-01
影响因子：
4.8
通讯作者：
Müller, HW
中科院分区：
文献类型：
--
作者：
Küry, P;Stoll, G;Müller, HW
与中枢神经系统相反，周围神经系统具有内在的再生能力。人们很早以前就认识到，只有经过广泛的清理程序（即所谓的沃勒变性）才能实现这一目标，其中髓磷脂碎片被去除并产生适合轴突生长的环境。沃勒变性和再生过程本身都依赖于直接的细胞相互作用以及所有参与细胞类型之间的远程信号。阐明这些信号的性质和功能后果是了解周围神经修复的主要目标。当前神经学观点 14：635-639。 (C) 2001 年利平科特威廉姆斯和威尔金斯。
The peripheral nervous system, as opposed to the central nervous system, has the intrinsic capacity to regenerate. It was recognized long ago that this can be achieved only after an extensive clean-up procedure, the so-called Wallerian degeneration, in which myelin debris is removed and a suitable environment for growing axons is generated. Wallerian degeneration and the regeneration process itself both depend on direct cellular interactions as well as on long-range signals between all participating cell types. Elucidating the nature and functional consequences of these signals is a main goal in understanding peripheral nerve repair. Curr Opin Neurol 14:635-639. (C) 2001 Lippincott Williams & Wilkins.