Inhibitory effects of caffeine on hippocampal neurogenesis and function
Inhibitory effects of caffeine on hippocampal neurogenesis and function
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DOI：
10.1016/j.bbrc.2007.03.086
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发表时间：
2007-05-18
影响因子：
3.1
通讯作者：
Oh, Sae-Ock
中科院分区：
文献类型：
--
作者：
Han, Myoung-Eun;Park, Kyu-Hyun;Oh, Sae-Ock
咖啡因是世界上最广泛使用的精神兴奋剂之一。然而，与咖啡因的短期影响相比，咖啡因消费对学习和记忆的长期影响的特征很差。目前的研究发现，长期摄入低剂量咖啡因（0.3 g/L）会减缓大脑皮层依赖性学习，并损害长期记忆。与对照组相比，4周的咖啡因摄入也显着减少了海马神经发生。从这些结果中，我们得出结论，长期摄入咖啡因可以部分通过抑制海马神经发生来抑制海马依赖性学习和记忆。(c)2007爱思唯尔公司All rights reserved.
Caffeine is one of the most extensively consumed psycho stimulants in the world. However, compared to short-term effects of caffeine, the long-term effects of caffeine consumption on learning and memory are poorly characterized. The present study found that long-term consumption of low dose caffeine (0.3 g/L) slowed hippocampus-dependent learning and impaired long-term memory. Caffeine consumption for 4 weeks also significantly reduced hippocampal neurogenesis compared to controls. From these results, we concluded that long-term consumption of caffeine could inhibit hippocampus-dependent learning and memory partially through inhibition of hippocampal neurogenesis. (c) 2007 Elsevier Inc. All rights reserved.