Effectiveness of personal genomic testing for disease-prevention behavior when combined with careful consultation with a physician: a preliminary study.
Effectiveness of personal genomic testing for disease-prevention behavior when combined with careful consultation with a physician: a preliminary study.
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DOI：
10.1186/s13104-018-3330-9
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发表时间：
2018-04-03
影响因子：
1.8
通讯作者：
Yamashita N
中科院分区：
文献类型：
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作者：
Hayashi M;Watanabe A;Muramatsu M;Yamashita N
有许多直接面向消费者（DTC）类型的个人基因组检测（PGT）服务可商业化地提供给公众，提供个体的特定疾病易感性。虽然这些服务似乎没有刺激疾病预防行为，但很少有研究涉及这样做的方法。我们调查了将医生咨询与DTC型PGT的检测结果提供相结合的有效性，作为确定有效的疾病预防基因组检测的初步研究。一位有准备的医生披露了20名健康受试者的PGT结果，并为每位受试者提供了关于高危疾病的具体咨询。在PGT前、PGT后和PGT后3、6和12个月检查了对每个受试者的健康感、对未来可能疾病的理解和预防行为的影响。PGT治疗前后患者对生活方式对疾病发生的影响的认识（P < 0.05）和对影响疾病发生的能力的认识（P < 0.01）明显提高。随访问卷结果显示，超过60%的受试者改变了他们的生活方式，有利于疾病预防。这些结果表明，将DTC-PGT与仔细的医生咨询相结合可能有效地激励人们采取预防行为。本文的在线版本（10.1186/s13104-018-3330-9）包含补充材料，可供授权用户使用。
There are many direct-to-consumer (DTC)-type personal genomic testing (PGT) services commercially available to the public, providing the specific disease susceptibilities of individuals. While these services do not appear to stimulate disease-prevention behavior, few studies have addressed the methods to do so. We investigated the effectiveness of combining a consultation with a physician with the delivery of test results from a DTC-type PGT, as a preliminary study to identify the effective genomic testing for disease-prevention. A prepared physician disclosed the PGT results of twenty healthy subjects and provided a specific consultation on the high-risk diseases for each subject. The effects on the sense of health, understanding of possible future diseases, and preventive behaviors for each subject were examined pre-PGT, post-PGT, and 3, 6, and 12 months post-PGT. Significant increases between the pre- and post-PGT scores were observed for the awareness of lifestyle effects on developing those diseases (P < 0.05) and the awareness of the ability to influence disease onset (P < 0.01). The follow-up questionnaire results showed that over 60% of the subjects changed their lifestyles in favor of disease prevention. These results suggest that combining the DTC-PGT with a careful physician consultation may be effective at motivating people toward preventive behavior. The online version of this article (10.1186/s13104-018-3330-9) contains supplementary material, which is available to authorized users.