Sentence composition ability in two patients with non-fluent/agrammatic variant primary progressive aphasia
Sentence composition ability in two patients with non-fluent/agrammatic variant primary progressive aphasia
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两名不流利/语法错误变异型原发性进行性失语症患者的句子组成能力
DOI：
10.1111/psyg.12311
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发表时间：
2018
期刊：
影响因子：
2
通讯作者：
Mori Etsuro
中科院分区：
文献类型：
--
作者：
Watanabe Hiroyuki;Matsuda Minoru;Ota Shoko;Baba Toru;Iizuka Osamu;Mori Etsuro
语法缺失是非流利型/语法缺失变异型原发性进行性失语症的核心临床特征之一，在西方国家传统上被认为是非流利型失语症的标志。然而，由于语言的粘着结构和词序的高度灵活性，日语患者的语法错误言语可能仍然未被发现。在本研究中，我们的目的是分析失语症的日本患者由于神经退行性疾病，使用我们的实验室产生的变位测试的言语产生中的语法缺失。在2014年12月至2015年8月期间，从东北大学医院的痴呆症诊所招募了4名患者：2名患者患有非流利/语法变异型原发性进行性失语症，1名患者患有语义变异型原发性进行性失语症，1名患者可能患有阿尔茨海默病，经历了情节性记忆障碍并伴有经皮质感觉失语症。所有患者在进行基于西北字谜测试的日本字谜任务之前都进行了彻底的神经和神经心理测试。我们的研究结果表明，两名非流利/语法变异型原发性进行性失语症患者在变位词任务上表现出比其余两名患者更差的表现。因此，在本研究中使用的字谜测试可能有助于检测输出方面的失语症患者在日本，虽然未来的研究需要开发一个标准化版本的测试。
Agrammatism is one of the core clinical features of non‐fluent/agrammatic variant primary progressive aphasia, and it has traditionally been considered the hallmark of non‐fluent aphasia in Western countries. However, agrammatic speech may remain undetected in Japanese patients because of the agglutinative structure of the language and high flexibility in word order. In the present study, we aimed to analyze agrammatism in the speech production of Japanese patients with aphasia due to neurodegenerative disease using an anagram test generated by our laboratory. Four patients were recruited from the dementia clinic at Tohoku University Hospital between December 2014 and August 2015: two patients with non‐fluent/agrammatic variant primary progressive aphasia, one with semantic variant primary progressive aphasia, and one with probable Alzheimer's disease experiencing episodic memory impairment accompanied by transcortical sensory aphasia. All patients underwent thorough neurological and neuropsychological testing before performing a Japanese anagram task based on the Northwestern Anagram Test. Our findings indicated that the two patients with non‐fluent/agrammatic variant primary progressive aphasia exhibited poorer performance on the anagram task than the remaining two patients. Therefore, the anagram test used in the present study may aid in detecting output aspects of agrammatism in Japanese patients with aphasia, although future studies are required to develop a standardized version of test.