The Mediator Complex and Lipid Metabolism.
The Mediator Complex and Lipid Metabolism.
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发表时间：
2013-03
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通讯作者：
Yi Zhang;Xiaoli;Xiaoping Zhao;Fajun Yang
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作者：
Yi Zhang;Xiaoli;Xiaoping Zhao;Fajun Yang
基因表达的精确控制对于所有生物过程至关重要。除了 DNA 结合转录因子外，许多转录辅因子还对真核细胞中的基因转录起到另一层调控作用。其中一种转录辅因子是高度保守的介导复合物，它具有多个亚基，通过直接与相关转录因子相互作用参与多种生物过程。尽管目前对Mediator生物学功能的认识还不完整，但近十年的研究已经揭示了Mediator在调节脂质代谢中的重要作用。 Mediator 的这种功能依赖于特定的转录因子，包括过氧化物酶体增殖物激活受体-γ (PPARγ) 和甾醇调节元件结合蛋白 (SREBP)，它们代表脂质代谢的主要调节因子。这些发现的医学意义是显而易见的，因为脂质代谢异常与2型糖尿病和心血管疾病等主要人类疾病密切相关。在此，我们简要回顾一下Mediator调节脂质代谢的功能和分子机制。
The precise control of gene expression is essential for all biological processes. In addition to DNA-binding transcription factors, numerous transcription cofactors contribute another layer of regulation of gene transcription in eukaryotic cells. One of such transcription cofactors is the highly conserved Mediator complex, which has multiple subunits and is involved in various biological processes through directly interacting with relevant transcription factors. Although the current understanding on the biological functions of Mediator remains incomplete, research in the past decade has revealed an important role of Mediator in regulating lipid metabolism. Such function of Mediator is dependent on specific transcription factors, including peroxisome proliferator-activated receptor-gamma (PPARγ) and sterol regulatory element-binding proteins (SREBPs), which represent the master regulators of lipid metabolism. The medical significance of these findings is apparent, as aberrant lipid metabolism is intimately linked to major human diseases, such as type 2 diabetes and cardiovascular disease. Here, we briefly review the functions and molecular mechanisms of Mediator in regulation of lipid metabolism.