Design synthesis and biological evaluation of 3-substituted triazole derivatives
Design synthesis and biological evaluation of 3-substituted triazole derivatives
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3-取代三唑衍生物的设计合成及生物学评价
DOI：
10.1016/j.cclet.2010.11.029
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发表时间：
2011-05-01
影响因子：
9.1
通讯作者：
Wu, Qiu Ye
中科院分区：
文献类型：
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作者：
Wang, Bao Gang;Yu, Shi Chong;Wu, Qiu Ye
基于羊毛甾醇14 α-脱甲基酶活性位点，设计合成了16种1-（1H-1，2，4-三唑-1-基）-2-（2，4-二氟苯基）-3-（N-正丁基-N-1-取代苄基-4-亚甲基-1H-1，2，3-三唑）-2-丙醇类抗真菌剂。对八种人类病原真菌的初步体外抗真菌试验结果表明，部分化合物具有良好的广谱活性。(C)2010年，胡洪刚。Elsevier B.V代表中国化学会出版。All rights reserved.
Based on the active site of lanosterol 14 alpha-demethylase of azole antifungal agents, sixteen 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-(N-n-butyl-N-1-substitutedbenzyl-4-methylene-1H-1,2,3-triazole)-2-propanols have been designed, synthesized and evaluated as antifungal agents. Results of preliminary antifungal tests against eight human pathogenic fungi in vitro showed that some of the compounds exhibited excellent activities with broad spectrum. (C) 2010 Hong Gang Hu. Published by Elsevier B.V, on behalf of Chinese Chemical Society. All rights reserved.