Cushing's syndrome in childhood: update on genetics, treatment, and outcomes
Cushing's syndrome in childhood: update on genetics, treatment, and outcomes
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DOI：
10.1097/med.0000000000000127
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发表时间：
2015-02-01
影响因子：
3.2
通讯作者：
Lodish, Maya
中科院分区：
文献类型：
--
作者：
Lodish, Maya
综述的目的提供与儿童库欣综合征相关的基因的最新情况，并使临床医生熟悉库欣综合征儿童的最新治疗指南和结果数据。最新发现与库欣综合征相关的基因列表继续增长。此外，儿童库欣综合征的治疗方法也在不断发展。随着对儿童的长期随访数据的获得，临床医生需要意识到需要关注的问题。概述库欣综合征的特定遗传原因的知识对治疗、监测和咨询具有潜在的影响。外科技术、放射治疗和药物治疗的进步为库欣综合征提供了更多治疗选择的可能性。早期识别和管理治疗库欣综合征儿童的治疗后发病率对于优化护理至关重要。
Purpose of reviewTo provide an update on the genes associated with Cushing's syndrome in children, as well as to familiarize the clinician with recent treatment guidelines and outcome data for children with Cushing's syndrome.Recent findingsThe list of genes associated with Cushing's syndrome continues to grow. In addition, treatment for childhood Cushing's syndrome is evolving. As long-term follow-up data on children becomes available, clinicians need to be aware of the issues that require attention.SummaryKnowledge of the specific genetic causes of Cushing's syndrome has potential implications for treatment, surveillance, and counseling. Advances in surgical technique, radiation modalities, and medical therapies offer the potential for additional treatment options in Cushing's syndrome. Early identification and management of post-treatment morbidities in children treated for Cushing's syndrome is crucial in order to optimize care.