Effect of quantitative and qualitative diet prescription on children behavior after diagnosis of heterozygous familial hypercholesterolemia
Effect of quantitative and qualitative diet prescription on children behavior after diagnosis of heterozygous familial hypercholesterolemia
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DOI：
10.1016/j.ijcard.2019.05.069
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发表时间：
2019-10-15
影响因子：
3.5
通讯作者：
Borghi, Claudio
中科院分区：
文献类型：
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作者：
Cicero, Arrigo F. G.;Fogacci, Federica;Borghi, Claudio
背景：饮食和健康生活方式的改变是早期干预高胆固醇血症的首选治疗方法。我们的目的是评估定性饮食计划对杂合子家族性高胆固醇血症（heFH）患儿及其母亲的代谢参数和焦虑水平的影响，而不是定量饮食计划。方法：对42例heFH正常体重儿童（11.4 +/- 2.9岁）进行定性而非定量饮食改变后儿童感知生活质量和母亲焦虑水平的相关因素调查。结果：给药饮食具有相似的代谢作用。然而，较高的儿童行为检查表（行为问题子量表）[CBCL]得分与定量饮食的持久性、较高的儿童年龄、较高的儿童抑郁量表2 [CDI2]和儿童状态-特质焦虑量表[STAI-CH]得分以及基线时母亲的焦虑水平显著相关。结论：在heFH儿童中，干预饮食以改善食物选择似乎与更健康的儿童行为有关，而不是定量饮食。(C) 2019 Elsevier B.V.版权所有
Background: Diet and healthy modifications in lifestyle represent the first therapeutic approach for early intervention in hypercholesterolemia. We aimed to evaluate the impact of a qualitative dietetic program rather than a quantitative one on metabolic parameters and anxiety level of children affected by heterozygous familial hypercholesterolemia [heFH] and their mothers.Methods: In a sample of 42 heFH normalweight children (11.4 +/- 2.9 years old), we investigated the factors which were associated with children perceived quality of life and with their mothers' anxiety levels after qualitative dietary changes rather than after quantitative ones.Results: The administered diets had similar metabolic effects. However, higher Child Behavior Checklist (Behavior Problems subscale) [CBCL] scores were significantly associated with the permanence in quantitative diet, as well as children's higher age, higher Children's Depression Inventory 2 [CDI2] and State-Trait Anxiety Inventory for Children [STAI-CH] score, and with mothers' anxiety at the baseline.Conclusion: In heFH children, an intervention in the diet to improve food choice seems to be associated with a more healthy children behavior rather than a quantitative diet. (C) 2019 Elsevier B.V. All rights reserved.