Function of Orofacial Stem Cells in Tooth Eruption: An Evolving Perspective
Function of Orofacial Stem Cells in Tooth Eruption: An Evolving Perspective
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口面部干细胞在牙齿萌出中的功能：一个不断发展的观点
DOI：
10.3290/j.cjdr.b1965049
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发表时间：
2021
影响因子：
0.9
通讯作者：
Fan Y
中科院分区：
文献类型：
--
作者：
Yu Y;Cui C;Guan S;Xu R;Zheng L;Zhou X;Fan Y
牙齿萌出与牙列的正常发育和咬合关系的建立密切相关。牙齿萌出的障碍可能会影响口腔生理功能，面部轮廓和美学;因此，了解萌出过程非常重要。这一过程是一个复杂的生物学事件，涉及组织和细胞水平的动态变化。它由解剖结构以及生物和分子因素引导，导致牙齿移动到口腔中的最终功能位置。越来越多的证据表明，干细胞有助于牙齿发育和萌出。已经在牙齿及其支持组织中发现了多种干细胞群，例如牙囊前体细胞、口面骨/骨髓来源的间充质干细胞、牙周韧带干细胞、来自根尖乳头的干细胞和牙髓干细胞。这些干细胞表现出独特的分化能力，并与牙槽骨改建，牙周组织发育和牙根形成过程中的爆发过程密切相关。本综述总结了目前的知识的特点和功能的口面干细胞在牙齿萌出，特别是最近的发现，其谱系分配和调节机制的重点。
Tooth eruption is closely linked to the normal development of dentition and proper establishment of occlusion. Disturbances in tooth eruption may affect oral physiological functions, facial contour and aesthetics; it is therefore important to understand the eruption process. This process is a complex biological event involving dynamic changes at the tissue and cellular levels. It is guided by anatomical structures as well as biological and molecular factors that result in the movement of the tooth to its final functional position in the oral cavity. Evidence increasingly suggests that stem cells contribute to tooth development and eruption. Multiple stem cell populations have been discovered in teeth and in their supporting tissues, such as dental follicle precursor cells, orofacial bone–/bone marrow–derived mesenchymal stem cells, periodontal ligament stem cells, stem cells from the apical papilla and dental pulp stem cells. These stem cells exhibit distinct differentiation capacities and are closely linked to alveolar bone remodelling, periodontium development and root formation during the eruption process. The present review summarises the current knowledge of the characteristics and functions of orofacial stem cells in tooth eruption, with a particular focus on recent discoveries concerning their lineage allocation and regulatory mechanisms.