Effect of alpha 2-adrenergic, cholinergic, and nonsteroidal anti-inflammatory drugs on myoelectric activity of ileum, cecum, and right ventral colon and on cecal emptying of radiolabeled markers in clinically normal ponies.
Effect of alpha 2-adrenergic, cholinergic, and nonsteroidal anti-inflammatory drugs on myoelectric activity of ileum, cecum, and right ventral colon and on cecal emptying of radiolabeled markers in clinically normal ponies.
复制标题
α2-肾上腺素能、胆碱能和非甾体抗炎药对临床正常小马回肠、盲肠和右腹结肠的肌电活动以及放射性标记标记的盲肠排空的影响。
DOI：
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发表时间：
1998
影响因子：
1
通讯作者：
B. Rice
中科院分区：
文献类型：
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作者：
G. Lester;Merritt Am;L. Neuwirth;T. Vetro;C. Steible;B. Rice
目标
旨在确定盐酸赛拉嗪 (XYL)、盐酸育亨宾 (YOH)、氯化氨胆碱 (BET)、甲基硫酸新斯的明 (NEO) 或氟尼辛葡甲胺 (FLU) 对回盲肠肌电活动和放射性标记标记物从盲肠通过的影响。
动物
6匹健康的成年小马。
程序
通过手术植入盲肠插管，并将 12 个盲肠插管缝合到回肠、盲肠和右腹结肠。 12小时禁食期后，将卵清中的370MBq锝99m标记的硫胶体和60ml水中的37MBq铟111标记的二乙基三胺五乙酸注射到盲肠尖。所有药物均通过静脉注射给药。作为丸剂，NEO 除外，其给予 SC：XYL，0.5 mg/kg 体重； YOH，0.075 毫克/千克； BET，0.025 毫克/千克； NEO，0.025毫克/千克；流感，1.1毫克/公斤；和盐溶液 (SAL)，10 ml。药物以随机完整区组设计施用，每种治疗对每匹小马施用两次，并获得双相闪烁扫描图像。达到 50% 排空的时间 (t50) 和排空曲线的斜率 (beta) 由计算的幂指数方程得出。
结果
BET（184.8+/-16.5分钟）和NEO（124.7+/-16.5分钟）施用后的t50显着短于盐水（230.2+/-17.1分钟）施用后的值。与盐水施用后的t50相比，XYL施用后的t50（250.5+/-18.6分钟）较长，而YOH施用后的t50（190.1+/-16.2分钟）较短，但两者差异均不显着。施用 FLU 后的 t50 和 β 与施用盐水后的不同。肌电数据似乎与药物引起的同位素清除变化密切相关。
结论和临床相关性
胆碱能激动剂 BET 和 NEO 对回肠、盲肠和右腹结肠的肌电活动具有显着影响，具有加速盲肠排空的净效应。
OBJECTIVE
To determine effect of xylazine hydrochloride (XYL), yohimbine hydrochloride (YOH), bethanechol chloride (BET), neostigmine methyl sulfate (NEO), or flunixin meglumine (FLU) on ileocecocolic myoelectric activity and passage of radiolabeled markers from the cecum.
ANIMALS
6 healthy adult ponies.
PROCEDURE
A cecal cannula was surgically implanted, and 12 were sutured to the ileum, cecum, and right ventral colon. After a 12-hour nonfeeding period, 370 MBq of technetium 99m-labeled sulfur colloid in egg albumen and 37 MBq of indium 111-labeled diethyltriaminepentaacetic acid in 60 ml of water were injected into the cecal apex. All drugs were administered i.v. as a bolus, with the exception of NEO, which was given SC: XYL, 0.5 mg/kg of body weight; YOH, 0.075 mg/kg; BET, 0.025 mg/kg; NEO, 0.025 mg/kg; FLU, 1.1 mg/kg; and saline solution (SAL), 10 ml. Drugs were administered in a randomized complete block design, each treatment was administered twice to each pony, and dual-phase scintigraphic images were obtained. The time to 50% emptying (t50) and the slope of the emptying curve (beta) were derived from the calculated power exponential equation.
RESULTS
The t50 after BET (184.8 +/- 16.5 minutes) and NEO (124.7 +/- 16.5 minutes) administration were significantly shorter than values after saline (230.2 +/- 17.1 minutes) administration. The t50 after XYL administration (250.5 +/- 18.6 minutes) was longer, and that after YOH administration (190.1 +/- 16.2 minutes) was shorter, than the t50 after saline administration, but neither difference was significant. The t50 and beta after FLU administration differed from those after saline administration. Myoelectric data appeared to be well correlated with drug-induced alterations in isotope clearance.
CONCLUSIONS AND CLINICAL RELEVANCE
Cholinergic agonists, BET and NEO, have significant effects on the myoelectric activity of ileum, cecum, and right ventral colon, with the net effect of hastening cecal emptying.