Inhibition of a Porphyromonas gingivalis colonizing factor between Actinomyces viscosus ATCC 19246 by monoclonal antibodies against recombinant 40-kDa outer-membrane protein
Inhibition of a Porphyromonas gingivalis colonizing factor between Actinomyces viscosus ATCC 19246 by monoclonal antibodies against recombinant 40-kDa outer-membrane protein
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DOI：
10.1016/s0306-3623(96)00366-7
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发表时间：
1997-05-01
期刊：
影响因子：
--
通讯作者：
Abiko, Y
中科院分区：
文献类型：
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作者：
Saito, S;Hiratsuka, K;Abiko, Y
1.牙龈卟啉单胞菌是人类牙周病的重要病原菌，与粘性放线菌ATCC 19246.2聚集。用抗牙龈卟啉单胞菌381重组40-kDa外膜蛋白（r40-kDa OMP）的单克隆抗体（mAb）抑制其与A.粘性酵母ATCC 19246以剂量依赖性的方式。选择5个抗r40-kDa OMP的mAb克隆。5株的同种型均为IgG1.4。Pg-ompA2抑制几株牙龈卟啉单胞菌与A. viscosus ATCC 19246细胞。(C)1997年爱思唯尔科学公司
1. Porphyromonas gingivalis, an important pathogen in human periodontal disease, aggregates with Actinomyces viscosus ATCC 19246.2. Monoclonal antibodies (mAbs) against purified recombinant 40-kDa outer membrane protein (r40-kDa OMP) of P. gingivalis 381 inhibited its coaggregation with A. viscosus ATCC 19246 in a dose-dependent manner.3. Five mAb clones against r40-kDa OMP were selected. The isotype of the five was IgG1.4. Pg-ompA2 inhibited the coaggregation of several strains of P. gingivalis with A. viscosus ATCC 19246 cells. (C) 1997 Elsevier Science Inc.