DPTA-catalyzed one-pot regioselective synthesis of polysubstituted pyridines and 1,4-dihydropyridines
DPTA-catalyzed one-pot regioselective synthesis of polysubstituted pyridines and 1,4-dihydropyridines
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DOI：
10.1016/j.tet.2012.03.104
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发表时间：
2012-06-03
期刊：
影响因子：
2.1
通讯作者：
Yu, Chuanming
中科院分区：
文献类型：
--
作者：
Li, Jianjun;He, Ping;Yu, Chuanming
以三酸二苯铵（DPAT）为催化剂，在无溶剂条件下，以醛、酮、胺为原料，通过一锅多组分反应制备了高取代吡啶和二氢吡啶。该工艺具有产率高、氮源环保、反应条件温和、操作简单等优点。研究了尿素、硫脲、无机铵盐和有机胺等不同来源的氮。此外，还开发了一种将伯脂肪胺转化为醇的新方法。(C) 2012 Elsevier Ltd.版权所有。
With diphenylammonium triflate (DPAT) as a catalyst, the highly substituted pyridines and dihydropyridines were prepared under solvent-free conditions from aldehydes, ketones, and amines via a one-pot multi-component reaction. The advantages of this protocol include excellent yields, environmentally benign source of nitrogen, mild reaction conditions, and simple manipulation. Different source of nitrogen like urea, thiourea, inorganic ammonium salts, and organic amines were studied. In addition, a novel way was developed for the conversion of primary aliphatic amines into alcohols. (C) 2012 Elsevier Ltd. All rights reserved.