3D Multiecho Dixon for the Evaluation of Hepatic Iron and Fat in a Clinical Setting
3D Multiecho Dixon for the Evaluation of Hepatic Iron and Fat in a Clinical Setting
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DOI：
10.1002/jmri.25630
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发表时间：
2017-09-01
影响因子：
4.4
通讯作者：
Kremser, Christian
中科院分区：
文献类型：
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作者：
Henninger, Benjamin;Zoller, Heinz;Kremser, Christian
目的：前瞻性评价新型3D-多回波-狄克逊（3D-ME-狄克逊）序列用于临床环境中肝脏铁和脂肪的定量。材料和方法：在2013年12月至2015年6月期间，共120名患者接受了肝脏的1.5T磁共振成像，包括以下三个序列：3D-ME-狄克逊，具有R2* 和质子密度脂肪分数（PDFF）图的内联计算、单体素光谱（SVS）、2D多梯度回波序列（2D-MEGRE）。SVS和2D-ME-GRE分别用作PDFF和R2* 的参考。将3D-MEDixon的R2* 和PDFF值与参考值进行比较。线性回归分析，Bland-Altman图，和协议parameters calculated.Results：在总数，103例患者最终纳入（87名男性和16名女性;平均年龄，50.51岁）; 17/120被排除，由于脂肪/水交换或R2* 值超过3D-ME-狄克逊的限制400 1/s。3D-ME-狄克逊的R2* 与2D-ME-GRE的R2* 之间存在较强的相关性（r=50.992，P < 0.001），Bland-Altman分析显示3D-ME-狄克逊的R2 * 值较低（16.499%）。使用57 1/s的适应阈值，3D-ME-狄克逊检测肝脏铁过载的阳性/阴性百分比一致率（PPA/NPA）为84.4%/91.4%。3D-ME-狄克逊序列与参考SVS的相关性较强（r50.957，P < 0.001），PPA/NPA分别为88.3%/91.4%。结论：3D-ME-狄克逊序列是一种有价值的肝脏铁和脂肪定量分析工具。脂肪/水交换仍然是一个缺点，需要改进实施方式，并且在最终发生的情况下，需要手头有经证明的常规序列。
Purpose: To prospectively evaluate a new 3D-multiecho-Dixon (3D-ME-Dixon) sequence for the quantification of hepatic iron and fat in a clinical setting.Materials and Methods: In all, 120 patients underwent 1.5T magnetic resonance imaging of the liver between December 2013 and June 2015 including the following three sequences: 3D-ME-Dixon with inline calculation of R2* and proton-density fat-fraction (PDFF) maps, single-voxel-spectroscopy (SVS), 2D multigradient-echo sequence (2D-MEGRE). SVS and 2D-ME-GRE were used as reference for PDFF and R2*, respectively. R2*- and PDFF-values from 3D-MEDixon were compared with those of the reference. Linear regression analysis, Bland-Altman plots, and agreement parameters were calculated.Results: In total, 103 patients were finally included (87 men and 16 women; mean age, 50.51 years); 17/120 were excluded due to fat/water-swaps or R2*-values exceeding the constraint of 400 1/s for 3D-ME-Dixon. A strong correlation (r=50.992, P < 0.001) between R2* of 3D-ME-Dixon and the reference 2D-ME-GRE was found. Bland-Altman analysis revealed systematically lower values for 3D-ME-Dixon (16.499%). Using an adapted threshold of 57 1/s, 3D-ME-Dixon obtained a positive/negative percentage agreement (PPA/NPA) of 84.4%/91.4% for detecting hepatic iron overload. For hepatic fat the correlation between 3D-ME-Dixon and the reference SVS was strong (r50.957, P < 0.001); PPA/NPA was 88.3%/91.4%.Conclusion: The 3D-ME-Dixon sequence is a valuable tool for the evaluation of hepatic iron and fat in a clinical setting. Fat/water-swaps remain a drawback requiring improvements to the implementation and making it necessary to have proven conventional sequences at hand in case of an eventual occurrence.