Metal-Free Catalytic Formylation of Amides Using CO2 under Ambient Conditions
Metal-Free Catalytic Formylation of Amides Using CO2 under Ambient Conditions
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DOI：
10.1021/acscatal.8b04023
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发表时间：
2018-12-01
期刊：
影响因子：
12.9
通讯作者：
Mandal, Swadhin K.
中科院分区：
文献类型：
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作者：
Hota, Pradip Kumar;Sau, Samaresh Chandra;Mandal, Swadhin K.
This study reports the metal-free formylation of amides using carbon dioxide under ambient conditions. An abnormal N-heterocyclic carbene (aNHC) acts as an efficient catalyst for the formylation of amides in the presence of hydrosilane at room temperature. This methodology enables the formation of a C-N bond and can be utilized in building up core moieties of two natural products having strong larvicidal activity such as alatamide and lansiumamide A. A preliminary mechanistic picture for this transformation has been proposed through isolation of reaction byproduct (confirmed by single crystal X-ray study) as well as by characterizing intermediates with spectroscopy.
