Synthesis and hemolytic properties of arvensoside B isomers
Synthesis and hemolytic properties of arvensoside B isomers
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DOI：
10.1007/s007060070055
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发表时间：
2000-09-01
影响因子：
1.8
通讯作者：
Haslinger, E
中科院分区：
文献类型：
--
作者：
Seebacher, W;Weis, R;Haslinger, E
本文首次报道半乳糖基-葡萄糖基油酸二糖的部分合成。从不同连接的乙酰溴糖制备了早期从金盏花和药用金盏花中分离的阿文皂苷B和金盏花皂苷A以及一些其他的油酸糖苷。研究了这些皂苷的溶血特性。碳水化合物结构的系统变化和与已经合成的葡糖基-葡糖基类似物的比较使关于结构-活性关系的一般结论成为可能。
The first partial syntheses of galactosyl-glucosyl oleanolic acid disaccharides are described. Arvensoside B and calenduloside A, which have earlier been isolated from Calendula arvensis and Calendula officinalis, and some further oleanolic acid glycosides were prepared from differently linked acetobromo sugars. The hemolytic properties of these saponins were investigated. Systematic variation of the carbohydrate structure and comparison with already synthesized glucosyl-glucosyl analogues enable general conclusions about structure-activity relationships.