Time Trends in Brain Tumor Incidence Rates in Denmark, Finland, Norway, and Sweden, 1974-2003
Time Trends in Brain Tumor Incidence Rates in Denmark, Finland, Norway, and Sweden, 1974-2003
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DOI：
10.1093/jnci/djp415
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发表时间：
2009-12-16
期刊：
影响因子：
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通讯作者：
Schuz, Joachim
中科院分区：
文献类型：
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作者：
Deltour, Isabelle;Johansen, Christoffer;Schuz, Joachim
在丹麦、芬兰、挪威和瑞典，移动电话的使用在20世纪90年代中期急剧增加；因此，1998年以后脑肿瘤发病率的时间趋势可能提供与手机使用有关的可能肿瘤风险的信息。我们调查了1974年至2003年丹麦、芬兰、挪威和瑞典胶质瘤和脑膜瘤发病率的时间趋势，使用了国家癌症登记处的数据。我们使用连接点回归模型来分析神经胶质瘤和脑膜瘤的年发病率。在此期间，在1600万成年人中，有59984名年龄在20-79岁之间的男性和女性被诊断患有脑肿瘤。所有统计检验均为双侧检验。从1974年到2003年，胶质瘤的发病率在男性中每年增加0.5%(95%可信区间[CI] = 0.2%至0.8%)，在女性中每年增加0.2% (95% CI = -0.1%至0.5%)，脑膜瘤的发病率在男性中每年增加0.8% (95% CI = 0.4%至1.3%)，在20世纪90年代初之后，在女性中每年增加3.8% （95% CI = 3.2%至4.4%）。从1998年到2003年没有观察到发病率趋势的变化，这段时间移动电话使用与癌症风险之间可能存在关联，这段时间可以提供5-10年的诱导期信息。
In Denmark, Finland, Norway, and Sweden, the use of mobile phones increased sharply in the mid-1990s; thus, time trends in brain tumor incidence after 1998 may provide information about possible tumor risks associated with mobile phone use. We investigated time trends in the incidence of glioma and meningioma in Denmark, Finland, Norway, and Sweden from 1974 to 2003, using data from national cancer registries. We used joinpoint regression models to analyze the annual incidence rates of glioma and meningioma. During this period, 59 984 men and women aged 20-79 years were diagnosed with brain tumors in a population of 16 million adults. All statistical tests were two-sided. From 1974 to 2003, the incidence rate of glioma increased by 0.5% per year (95% confidence interval [CI] = 0.2% to 0.8%) among men and by 0.2% per year (95% CI = -0.1% to 0.5%) among women and that of meningioma increased by 0.8% per year (95% CI = 0.4% to 1.3%) among men, and after the early 1990s, by 3.8% per year (95% CI = 3.2% to 4.4%) among women. No change in incidence trends were observed from 1998 to 2003, the time when possible associations between mobile phone use and cancer risk would be informative about an induction period of 5-10 years.