Genome-Wide Screening for Risk Loci of Idiopathic Recurrent Miscarriage in a Han Chinese Population: A Pilot Study
Genome-Wide Screening for Risk Loci of Idiopathic Recurrent Miscarriage in a Han Chinese Population: A Pilot Study
复制标题
DOI：
10.1177/1933719110364248
复制
发表时间：
2010-06
影响因子：
2.9
通讯作者：
Li Wang;Zeng Chan Wang;Cui Xie;Xiao Feng Liu;Mao Sheng Yang
中科院分区：
文献类型：
--
作者：
Li Wang;Zeng Chan Wang;Cui Xie;Xiao Feng Liu;Mao Sheng Yang
复发性流产（RM）的病因是非常异质性的，包括遗传，免疫，解剖，内分泌和感染异常。约50%的RM无法解释或了解不多，称为特发性复发性流产（idiopathic recurrent miscarriage，简称RRM）。本研究的主要目的是确定可能对甲流易感的遗传位点。本研究纳入了44例汉族妊娠早期子宫内膜异位症患者和44例性别和种族匹配的健康对照。进行了病例对照和全基因组研究，并分析了430个多态性微卫星标记。结果发现6q27（D6S446，P = .028）、9q33.1（D9S1776，P = .037）和Xp22.11（DXS1226，P = .008）3个基因位点与Escherichia coli显著相关，为Escherichia coli的遗传学和病因学研究提供了新的思路。需要进一步的研究来证实这一点。
The etiology of recurrent miscarriage (RM) is extremely heterogeneous, including genetic, immunologic, anatomic, endocrinological, and infectious anomalies. About 50% of RM is unexplained or poorly understood, which is called idiopathic recurrent miscarriage (IRM). The primary aim of this study was to identify the genetic loci that might be susceptible to IRM. Forty-four Han Chinese patients with IRM during the first trimester of their pregnancies and 44 healthy sex- and ethnic-matched controls were enrolled in this study. A case—control and genome-wide study was performed and 430 polymorphic microsatellite markers were analyzed. Three loci, 6q27 (D6S446, P = .028), 9q33.1 (D9S1776, P = .037), and Xp22.11 (DXS1226, P = .008), significantly associated with IRM were found. This work identified 3 genetic regions that might harbor genes predisposed to IRM and provided new insights for future genetic and etiological study of IRM. Further study is required to confirm it.