Using HE4, RMI, ROMA and CPH-I in the differential diagnosis of adnexal masses
Using HE4, RMI, ROMA and CPH-I in the differential diagnosis of adnexal masses
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HE4、RMI、ROMA和CPH-I在附件肿块鉴别诊断中的应用
DOI：
10.31083/j.ejgo.2021.01.2192
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发表时间：
2021-02
影响因子：
0.4
通讯作者：
Xing-Sheng Yang
中科院分区：
文献类型：
--
作者：
Zhen Shen;Chen-Chen Zhu;Li-Li Qian;Tian-Jiao Zhang;Min Li;Jing Zhu;Da-Bao Wu;Ying Zhou;Xing-Sheng Yang
目的：为了提高卵巢癌（OC）的早期诊断，我们评估了人附睾分泌蛋白4 （HE4）、恶性肿瘤风险指数（RMI）、卵巢恶性肿瘤风险算法（ROMA）和哥本哈根指数（cph - 1）预测附件肿块恶性风险的能力，以及区分浆液性和黏液性卵巢肿瘤的能力。方法：对509例诊断为良性、交界性和恶性附件肿瘤的患者进行研究。我们分析了HE4、RMI、ROMA和CPH-I的值。此外，还评估了CA125、CEA、CA125/CEA比值、CA199和CA125/CA199比值，以确定其对卵巢浆液性或黏液性肿瘤的诊断价值。结果：为了区分良性和交界性卵巢肿瘤，我们评估了RMI和CPH-I评分，结果显示AUC较高（分别为0.7593和0.7128），但两者的敏感性和特异性都不高。在鉴别良恶性肿瘤时，RMI和cph - 1在绝经前妇女中表现最好；而ROMA和HE4对绝经后妇女效果最好。CA125 （bbb328.3 U/mL）、CA125/CEA （bbb82.26）和CA125/CA199 （bbb5.633）高于临界值的患者更容易被诊断为浆液性癌。而CEA（> 3.7µg/L）和CA199 （> 27.81 ng/mL）较高的患者患黏液癌的可能性更大。结论：绝经前妇女的RMI和cph - 1，绝经后妇女的ROMA和RMI是鉴别妇女肿瘤良恶性的可靠指标。此外，CA125/CEA和CA125/CA199比值可用于区分浆液性和黏液性卵巢癌。
Objectives: In order to improve the early diagnosis of ovarian cancer (OC), we evaluated human epididymis secretory protein 4 (HE4), the risk of malignancy index (RMI), the risk of ovarian malignancy algorithm (ROMA), and the Copenhagen Index (CPH-I) in their ability to predict the risk of adnexal masses being malignant, and in discriminating between serous and mucinous ovarian tumors. Methods: A study consisting of 509 patients who were diagnosed with benign, borderline, and malignant adnexal tumors was conducted. We analyzed the values of HE4, RMI, ROMA, and CPH-I. In addition, CA125, CEA, CA125/CEA ratio, CA199, and CA125/CA199 ratio were also assessed to determine their predictive values to diagnoses serous or mucinous ovarian tumors. Results: To di ferentiate between benign and borderline ovarian tumors, we evaluated RMI and CPH-I scores which showed high AUC (0.7593, and 0.7128, respectively), but neither of them showed both high sensitivity and specificity. When discriminating benign and malignant tumors, RMI and CPH-I performed the best for premenopausal women; whereas ROMA and HE4 performed the best for postmenopausal women. Patients with values above the cuto f for CA125 (> 328.3 U/mL), CA125/CEA (> 82.26), and CA125/CA199 (> 5.633), were more likely to be diagnosed with serous carcinoma. Whereas those with higher values for CEA (> 3.7 µg/L) and CA199 (> 27.81 ng/mL) were more likely to have a mucinous carcinoma. Conclusion: RMI and CPH-I for premenopausal women, ROMA and RMI for postmenopausal women were reliable indicators to di ferentiate between women with benign versus malignant tumors. In addition, the ratios CA125/CEA and CA125/CA199 could be used to distinguish serous from mucinous ovarian carcinomas.
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DOI：
10.1891/9780826121646.0002
发表时间：
2018-09
期刊：
Cancer Rehabilitation
影响因子：
--
作者：
K. Miller;R. Siegel;R. Khan;A. Jemal
通讯作者：
K. Miller;R. Siegel;R. Khan;A. Jemal
DOI：
--
发表时间：
--
期刊：
--
影响因子：
--
作者：
通讯作者：
--
影响因子：
4.7
作者：
Lycke, Maria;Kristjansdottir, Bjorg;Sundfeldt, Karin
通讯作者：
Sundfeldt, Karin
影响因子：
2.7
作者：
Kim, Boyeon;Park, Yongjung;Han, Sang Won
通讯作者：
Han, Sang Won
影响因子：
4
作者：
Hada, Abha;Han, Li-ping;Liu, Liya
通讯作者：
Liu, Liya